Composite formation from hydroxyapatite with sodium and potassium salts of polyphosphazene

Y. E. Greish, J. D. Bender, S. Lakshmi, P. W. Brown, Harry R. Allcock, C. T. Laurencin

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The low temperature synthesis of composites potentially suitable as bone substitutes which form in vivo, was investigated. The composites were comprised of stoichiometric hydroxyapatite (SHAp) and water-soluble poly phosphazenes. These constituents were selected because of their biocompatibility, and were mixed as powders with a phosphate buffer solution (PBS) to form the composites. The effects of poly[bis(sodium carboxylatophenoxy)phosphazene] (Na-PCPP) or poly[bis(potassium carboxylatophenoxy) phosphazene] (K-PCPP) on stoichiometric hydroxyapatite (SHAp) formation from tetracalcium phosphate and anhydrous dicalcium phosphate were assessed. The kinetics and reaction chemistries of composite formation were followed by isothermal calorimetry, X-ray diffraction, infrared spectroscopy and scanning electron microscopy. In the presence of 1% by weight of polyphosphazenes, composites comprised of SHAp and calcium cross-linked polymer salts were formed. Thus a mechanism for binding between polymer chains was established. Elevated proportions (5 and 10% by weight) of polyphosphazene, however, resulted in the inhibition of SHAp formation. This is attributed to the formation of viscous polymer solution coatings on the calcium phosphate precursors, retarding their reaction, and consequently inhibiting SHAp formation.

Original languageEnglish (US)
Pages (from-to)613-620
Number of pages8
JournalJournal of Materials Science: Materials in Medicine
Volume16
Issue number7
DOIs
StatePublished - Jul 1 2005

Fingerprint

Durapatite
Hydroxyapatite
Potassium
Salts
Sodium
Composite materials
Polymers
Phosphates
Bone Substitutes
Weights and Measures
Calorimetry
Calcium phosphate
Polymer solutions
Biocompatibility
X-Ray Diffraction
Electron Scanning Microscopy
Powders
Infrared spectroscopy
Calcium
Spectrum Analysis

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Cite this

Greish, Y. E. ; Bender, J. D. ; Lakshmi, S. ; Brown, P. W. ; Allcock, Harry R. ; Laurencin, C. T. / Composite formation from hydroxyapatite with sodium and potassium salts of polyphosphazene. In: Journal of Materials Science: Materials in Medicine. 2005 ; Vol. 16, No. 7. pp. 613-620.
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Composite formation from hydroxyapatite with sodium and potassium salts of polyphosphazene. / Greish, Y. E.; Bender, J. D.; Lakshmi, S.; Brown, P. W.; Allcock, Harry R.; Laurencin, C. T.

In: Journal of Materials Science: Materials in Medicine, Vol. 16, No. 7, 01.07.2005, p. 613-620.

Research output: Contribution to journalArticle

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