Computational analysis of protein structures: Sources, methods, systems and results

Arthur M. Lesk, Anna Tramontano

Research output: Contribution to journalConference article

4 Citations (Scopus)

Abstract

Computational molecular biology is a relatively new specialty that has arisen in response to the very large amount and quality of data currently being produced, including gene and protein sequences ('one-dimensional' information) and nucleic acid and protein structures ('three-dimensional' information). Many important biological investigations can be carried out only through effective computational access to the entire corpus of data. This has stimulated the development of data banks and information retrieval systems. For example, after determination of a new gene sequence, one would like to know whether it is possible to say anything about its structure and function. To try to answer this question one screens the sequence of the corresponding protein for a significant similarity to a protein of known structure. In this article we describe the kinds of inferences that are possible if such a relationship is found.

Original languageEnglish (US)
Pages (from-to)85-93
Number of pages9
JournalJournal of research of the National Bureau of Standards
Volume94
Issue number1
DOIs
StatePublished - Jan 1 1989
EventWorkshop on the Role of Numeric Databases in Materials and Biological Sciences - Philadelphia, PA, USA
Duration: Jun 26 1988Jun 26 1988

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Proteins
Genes
Molecular biology
Information retrieval systems
Nucleic acids

All Science Journal Classification (ASJC) codes

  • Engineering(all)

Cite this

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Computational analysis of protein structures : Sources, methods, systems and results. / Lesk, Arthur M.; Tramontano, Anna.

In: Journal of research of the National Bureau of Standards, Vol. 94, No. 1, 01.01.1989, p. 85-93.

Research output: Contribution to journalConference article

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