Computational studies on pterins and speculations on the mechanism of action of dihydrofolate reductase

Tadafumi Uchimaru, Seiji Tsuzuki, Kazutoshi Tanabe, Stephen Benkovic, Kensuke Furukawa, Kazunari Taira

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Abstract

The significance of the enol form of the pterin ring in enzymatic reduction of dihydrofolate by DHFR is discussed on the basis of the results of ab initio calculations carried out on the keto/enol tautomers of 6-methyl-7,8-dihydropterin as the model compound for the natural substrate, dihydrofolate.

Original languageEnglish (US)
Pages (from-to)64-68
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume161
Issue number1
DOIs
Publication statusPublished - May 30 1989

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All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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