Computational studies on pterins and speculations on the mechanism of action of dihydrofolate reductase

Tadafumi Uchimaru, Seiji Tsuzuki, Kazutoshi Tanabe, Stephen Benkovic, Kensuke Furukawa, Kazunari Taira

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The significance of the enol form of the pterin ring in enzymatic reduction of dihydrofolate by DHFR is discussed on the basis of the results of ab initio calculations carried out on the keto/enol tautomers of 6-methyl-7,8-dihydropterin as the model compound for the natural substrate, dihydrofolate.

Original languageEnglish (US)
Pages (from-to)64-68
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume161
Issue number1
DOIs
StatePublished - May 30 1989

Fingerprint

Pterins
Tetrahydrofolate Dehydrogenase
Substrates
dihydrofolate
7,8-dihydropterin

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Uchimaru, Tadafumi ; Tsuzuki, Seiji ; Tanabe, Kazutoshi ; Benkovic, Stephen ; Furukawa, Kensuke ; Taira, Kazunari. / Computational studies on pterins and speculations on the mechanism of action of dihydrofolate reductase. In: Biochemical and Biophysical Research Communications. 1989 ; Vol. 161, No. 1. pp. 64-68.
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Computational studies on pterins and speculations on the mechanism of action of dihydrofolate reductase. / Uchimaru, Tadafumi; Tsuzuki, Seiji; Tanabe, Kazutoshi; Benkovic, Stephen; Furukawa, Kensuke; Taira, Kazunari.

In: Biochemical and Biophysical Research Communications, Vol. 161, No. 1, 30.05.1989, p. 64-68.

Research output: Contribution to journalArticle

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AU - Furukawa, Kensuke

AU - Taira, Kazunari

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