The significance of the enol form of the pterin ring in enzymatic reduction of dihydrofolate by DHFR is discussed on the basis of the results of ab initio calculations carried out on the keto/enol tautomers of 6-methyl-7,8-dihydropterin as the model compound for the natural substrate, dihydrofolate.
|Original language||English (US)|
|Number of pages||5|
|Journal||Biochemical and Biophysical Research Communications|
|Publication status||Published - May 30 1989|
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cell Biology