Computer-aided 4D modeling of hydrolytic degradation in micropatterned bioresorbable membranes

Ibrahim T. Ozbolat, Michelle Marchany, Joseph A. Gardella, Bahattin Koc

Research output: Contribution to journalArticle

Abstract

Real-time degradation studies of bioresorbable polymers can take weeks, months, and even years to conduct. For this reason, developing and validating mathematical models that describe and predict degradation can provide a means to accelerate the development of materials and devices for controlled drug release. This study aims to develop and experimentally validate a computer-aided model that simulates the hydrolytic degradation kinetics of bioresorbable polymeric micropatterned membranes for tissue engineering applications. Specifically, the model applies to circumstances that are conducive for the polymer to undergo surface erosion. The developed model provides a simulation tool enabling the prediction and visualization of the dynamic geometry of the degrading membrane. In order to validate the model, micropatterned polymeric membranes were hydrolytically degraded in vitro and the morphological changes were analyzed using optical microscopy. The model is then extended to predict spatiotemporal degradation kinetics of variational micropatterned architectures.

Original languageEnglish (US)
Article number021004
JournalJournal of Medical Devices, Transactions of the ASME
Volume7
Issue number2
DOIs
StatePublished - Jun 24 2013

Fingerprint

Membranes
Degradation
Polymers
Polymeric membranes
Tissue Engineering
Computer Simulation
Microscopy
Theoretical Models
Kinetics
Equipment and Supplies
Tissue engineering
Optical microscopy
Erosion
Visualization
Mathematical models
Geometry
Drug Liberation
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Biomedical Engineering

Cite this

@article{40393069cfc349f5a52b6e1a68570a87,
title = "Computer-aided 4D modeling of hydrolytic degradation in micropatterned bioresorbable membranes",
abstract = "Real-time degradation studies of bioresorbable polymers can take weeks, months, and even years to conduct. For this reason, developing and validating mathematical models that describe and predict degradation can provide a means to accelerate the development of materials and devices for controlled drug release. This study aims to develop and experimentally validate a computer-aided model that simulates the hydrolytic degradation kinetics of bioresorbable polymeric micropatterned membranes for tissue engineering applications. Specifically, the model applies to circumstances that are conducive for the polymer to undergo surface erosion. The developed model provides a simulation tool enabling the prediction and visualization of the dynamic geometry of the degrading membrane. In order to validate the model, micropatterned polymeric membranes were hydrolytically degraded in vitro and the morphological changes were analyzed using optical microscopy. The model is then extended to predict spatiotemporal degradation kinetics of variational micropatterned architectures.",
author = "Ozbolat, {Ibrahim T.} and Michelle Marchany and Gardella, {Joseph A.} and Bahattin Koc",
year = "2013",
month = "6",
day = "24",
doi = "10.1115/1.4024158",
language = "English (US)",
volume = "7",
journal = "Journal of Medical Devices, Transactions of the ASME",
issn = "1932-6181",
publisher = "American Society of Mechanical Engineers(ASME)",
number = "2",

}

Computer-aided 4D modeling of hydrolytic degradation in micropatterned bioresorbable membranes. / Ozbolat, Ibrahim T.; Marchany, Michelle; Gardella, Joseph A.; Koc, Bahattin.

In: Journal of Medical Devices, Transactions of the ASME, Vol. 7, No. 2, 021004, 24.06.2013.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Computer-aided 4D modeling of hydrolytic degradation in micropatterned bioresorbable membranes

AU - Ozbolat, Ibrahim T.

AU - Marchany, Michelle

AU - Gardella, Joseph A.

AU - Koc, Bahattin

PY - 2013/6/24

Y1 - 2013/6/24

N2 - Real-time degradation studies of bioresorbable polymers can take weeks, months, and even years to conduct. For this reason, developing and validating mathematical models that describe and predict degradation can provide a means to accelerate the development of materials and devices for controlled drug release. This study aims to develop and experimentally validate a computer-aided model that simulates the hydrolytic degradation kinetics of bioresorbable polymeric micropatterned membranes for tissue engineering applications. Specifically, the model applies to circumstances that are conducive for the polymer to undergo surface erosion. The developed model provides a simulation tool enabling the prediction and visualization of the dynamic geometry of the degrading membrane. In order to validate the model, micropatterned polymeric membranes were hydrolytically degraded in vitro and the morphological changes were analyzed using optical microscopy. The model is then extended to predict spatiotemporal degradation kinetics of variational micropatterned architectures.

AB - Real-time degradation studies of bioresorbable polymers can take weeks, months, and even years to conduct. For this reason, developing and validating mathematical models that describe and predict degradation can provide a means to accelerate the development of materials and devices for controlled drug release. This study aims to develop and experimentally validate a computer-aided model that simulates the hydrolytic degradation kinetics of bioresorbable polymeric micropatterned membranes for tissue engineering applications. Specifically, the model applies to circumstances that are conducive for the polymer to undergo surface erosion. The developed model provides a simulation tool enabling the prediction and visualization of the dynamic geometry of the degrading membrane. In order to validate the model, micropatterned polymeric membranes were hydrolytically degraded in vitro and the morphological changes were analyzed using optical microscopy. The model is then extended to predict spatiotemporal degradation kinetics of variational micropatterned architectures.

UR - http://www.scopus.com/inward/record.url?scp=84885070790&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84885070790&partnerID=8YFLogxK

U2 - 10.1115/1.4024158

DO - 10.1115/1.4024158

M3 - Article

AN - SCOPUS:84885070790

VL - 7

JO - Journal of Medical Devices, Transactions of the ASME

JF - Journal of Medical Devices, Transactions of the ASME

SN - 1932-6181

IS - 2

M1 - 021004

ER -