Abstract
The binding sites for 125I-monoiododerivative of apamin in the central nervous system of rat, guinea-pig, chicken and frog were analysed and compared by computer assisted quantitative densitometric autoradiography on X-ray film. The highest level of binding sites in the rat and guinea-pig brain was found in the limbic-olfactory system and in the substantia gelatinosa of the spinal cord. In the chicken brain apamin binds preferentially to the tectum opticum and nuclei isthmi. In the frog brain no specific apamin binding sites were found. The role of presented topography for apamin binding sites is discussed in relation to neurotoxic properties of apamin.
Original language | English (US) |
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Pages (from-to) | 240-249 |
Number of pages | 10 |
Journal | Acta Physiologica Polonica |
Volume | 40 |
Issue number | 2 |
State | Published - Dec 1 1989 |
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All Science Journal Classification (ASJC) codes
- Physiology
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Computer assisted quantitative densitometric analysis of 125I-apamin binding sites in the central nervous system. / Janicki, P. K.; Seibold, G.; Siembab, D.; Paulo, E. A.; Szreniawski, Z.
In: Acta Physiologica Polonica, Vol. 40, No. 2, 01.12.1989, p. 240-249.Research output: Contribution to journal › Article
TY - JOUR
T1 - Computer assisted quantitative densitometric analysis of 125I-apamin binding sites in the central nervous system
AU - Janicki, P. K.
AU - Seibold, G.
AU - Siembab, D.
AU - Paulo, E. A.
AU - Szreniawski, Z.
PY - 1989/12/1
Y1 - 1989/12/1
N2 - The binding sites for 125I-monoiododerivative of apamin in the central nervous system of rat, guinea-pig, chicken and frog were analysed and compared by computer assisted quantitative densitometric autoradiography on X-ray film. The highest level of binding sites in the rat and guinea-pig brain was found in the limbic-olfactory system and in the substantia gelatinosa of the spinal cord. In the chicken brain apamin binds preferentially to the tectum opticum and nuclei isthmi. In the frog brain no specific apamin binding sites were found. The role of presented topography for apamin binding sites is discussed in relation to neurotoxic properties of apamin.
AB - The binding sites for 125I-monoiododerivative of apamin in the central nervous system of rat, guinea-pig, chicken and frog were analysed and compared by computer assisted quantitative densitometric autoradiography on X-ray film. The highest level of binding sites in the rat and guinea-pig brain was found in the limbic-olfactory system and in the substantia gelatinosa of the spinal cord. In the chicken brain apamin binds preferentially to the tectum opticum and nuclei isthmi. In the frog brain no specific apamin binding sites were found. The role of presented topography for apamin binding sites is discussed in relation to neurotoxic properties of apamin.
UR - http://www.scopus.com/inward/record.url?scp=0024955917&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024955917&partnerID=8YFLogxK
M3 - Article
C2 - 2641421
AN - SCOPUS:0024955917
VL - 40
SP - 240
EP - 249
JO - Journal of Physiology and Pharmacology
JF - Journal of Physiology and Pharmacology
SN - 0867-5910
IS - 2
ER -