Computer assisted quantitative densitometric analysis of 125I-apamin binding sites in the central nervous system

P. K. Janicki, G. Seibold, D. Siembab, E. A. Paulo, Z. Szreniawski

Research output: Contribution to journal › Article

Abstract

The binding sites for 125I-monoiododerivative of apamin in the central nervous system of rat, guinea-pig, chicken and frog were analysed and compared by computer assisted quantitative densitometric autoradiography on X-ray film. The highest level of binding sites in the rat and guinea-pig brain was found in the limbic-olfactory system and in the substantia gelatinosa of the spinal cord. In the chicken brain apamin binds preferentially to the tectum opticum and nuclei isthmi. In the frog brain no specific apamin binding sites were found. The role of presented topography for apamin binding sites is discussed in relation to neurotoxic properties of apamin.

Original languageEnglish (US)
Pages (from-to)240-249
Number of pages10
JournalActa Physiologica Polonica
Volume40
Issue number2
StatePublished - Dec 1 1989

Fingerprint

Apamin
Central Nervous System
Binding Sites
Anura
Chickens
Brain
Guinea Pigs
Substantia Gelatinosa
Limbic System
X-Ray Film
Autoradiography
Spinal Cord

All Science Journal Classification (ASJC) codes

  • Physiology

Cite this

Janicki, P. K. ; Seibold, G. ; Siembab, D. ; Paulo, E. A. ; Szreniawski, Z. / Computer assisted quantitative densitometric analysis of 125I-apamin binding sites in the central nervous system. In: Acta Physiologica Polonica. 1989 ; Vol. 40, No. 2. pp. 240-249.
@article{3ccb4c6e465c422fa3fe6ed2e493b13a,
title = "Computer assisted quantitative densitometric analysis of 125I-apamin binding sites in the central nervous system",
abstract = "The binding sites for 125I-monoiododerivative of apamin in the central nervous system of rat, guinea-pig, chicken and frog were analysed and compared by computer assisted quantitative densitometric autoradiography on X-ray film. The highest level of binding sites in the rat and guinea-pig brain was found in the limbic-olfactory system and in the substantia gelatinosa of the spinal cord. In the chicken brain apamin binds preferentially to the tectum opticum and nuclei isthmi. In the frog brain no specific apamin binding sites were found. The role of presented topography for apamin binding sites is discussed in relation to neurotoxic properties of apamin.",
author = "Janicki, {P. K.} and G. Seibold and D. Siembab and Paulo, {E. A.} and Z. Szreniawski",
year = "1989",
month = "12",
day = "1",
language = "English (US)",
volume = "40",
pages = "240--249",
journal = "Journal of Physiology and Pharmacology",
issn = "0867-5910",
publisher = "Polish Physiological Society",
number = "2",

}

Janicki, PK, Seibold, G, Siembab, D, Paulo, EA & Szreniawski, Z 1989, 'Computer assisted quantitative densitometric analysis of 125I-apamin binding sites in the central nervous system', Acta Physiologica Polonica, vol. 40, no. 2, pp. 240-249.

Computer assisted quantitative densitometric analysis of 125I-apamin binding sites in the central nervous system. / Janicki, P. K.; Seibold, G.; Siembab, D.; Paulo, E. A.; Szreniawski, Z.

In: Acta Physiologica Polonica, Vol. 40, No. 2, 01.12.1989, p. 240-249.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Computer assisted quantitative densitometric analysis of 125I-apamin binding sites in the central nervous system

AU - Janicki, P. K.

AU - Seibold, G.

AU - Siembab, D.

AU - Paulo, E. A.

AU - Szreniawski, Z.

PY - 1989/12/1

Y1 - 1989/12/1

N2 - The binding sites for 125I-monoiododerivative of apamin in the central nervous system of rat, guinea-pig, chicken and frog were analysed and compared by computer assisted quantitative densitometric autoradiography on X-ray film. The highest level of binding sites in the rat and guinea-pig brain was found in the limbic-olfactory system and in the substantia gelatinosa of the spinal cord. In the chicken brain apamin binds preferentially to the tectum opticum and nuclei isthmi. In the frog brain no specific apamin binding sites were found. The role of presented topography for apamin binding sites is discussed in relation to neurotoxic properties of apamin.

AB - The binding sites for 125I-monoiododerivative of apamin in the central nervous system of rat, guinea-pig, chicken and frog were analysed and compared by computer assisted quantitative densitometric autoradiography on X-ray film. The highest level of binding sites in the rat and guinea-pig brain was found in the limbic-olfactory system and in the substantia gelatinosa of the spinal cord. In the chicken brain apamin binds preferentially to the tectum opticum and nuclei isthmi. In the frog brain no specific apamin binding sites were found. The role of presented topography for apamin binding sites is discussed in relation to neurotoxic properties of apamin.

UR - http://www.scopus.com/inward/record.url?scp=0024955917&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024955917&partnerID=8YFLogxK

M3 - Article

C2 - 2641421

AN - SCOPUS:0024955917

VL - 40

SP - 240

EP - 249

JO - Journal of Physiology and Pharmacology

JF - Journal of Physiology and Pharmacology

SN - 0867-5910

IS - 2

ER -

Janicki PK, Seibold G, Siembab D, Paulo EA, Szreniawski Z. Computer assisted quantitative densitometric analysis of 125I-apamin binding sites in the central nervous system. Acta Physiologica Polonica. 1989 Dec 1;40(2):240-249.

Access to Document