COMT val108/158 met genotype affects neural but not cognitive processing in healthy individuals

Nancy A. Dennis, Anna C. Need, Kevin S. Labar, Sheena Waters-Metenier, Elizabeth T. Cirulli, James Kragel, David B. Goldstein, Roberto Cabeza

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

The relationship between cognition and a functional polymorphism in the catechol-O-methlytransferase (COMT) gene, val108/158met, is one of debate in the literature. Furthermore, based on the dopaminergic differences associated with the COMT val108/158met genotype, neural differences during cognition may be present, regardless of genotypic differences in cognitive performance. To investigate these issues the current study aimed to 1) examine the effects of COMT genotype using a large sample of healthy individuals (n = 496-1218) and multiple cognitive measures, and using a subset of the sample (n = 22), 2) examine whether COMT genotype effects medial temporal lobe (MTL) and frontal activity during successful relational memory processing, and 3) investigate group differences in functional connectivity associated with successful relational memory processing. Results revealed no significant group difference in cognitive performance between COMT genotypes in any of the 19 cognitive measures. However, in the subset sample, COMT val homozygotes exhibited significantly decreased MTL and increased prefrontal activity during both successful relational encoding and retrieval, and reduced connectivity between these regions compared with met homozygotes. Taken together, the results suggest that although the COMT val108/158met genotype has no effect on cognitive behavioral measures in healthy individuals, it is associated with differences in neural process underlying cognitive output.

Original languageEnglish (US)
Pages (from-to)672-683
Number of pages12
JournalCerebral Cortex
Volume20
Issue number3
DOIs
StatePublished - Mar 1 2010

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Genotype
Homozygote
Temporal Lobe
Cognition
catechol
Genes

All Science Journal Classification (ASJC) codes

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Dennis, N. A., Need, A. C., Labar, K. S., Waters-Metenier, S., Cirulli, E. T., Kragel, J., ... Cabeza, R. (2010). COMT val108/158 met genotype affects neural but not cognitive processing in healthy individuals. Cerebral Cortex, 20(3), 672-683. https://doi.org/10.1093/cercor/bhp132
Dennis, Nancy A. ; Need, Anna C. ; Labar, Kevin S. ; Waters-Metenier, Sheena ; Cirulli, Elizabeth T. ; Kragel, James ; Goldstein, David B. ; Cabeza, Roberto. / COMT val108/158 met genotype affects neural but not cognitive processing in healthy individuals. In: Cerebral Cortex. 2010 ; Vol. 20, No. 3. pp. 672-683.
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Dennis, NA, Need, AC, Labar, KS, Waters-Metenier, S, Cirulli, ET, Kragel, J, Goldstein, DB & Cabeza, R 2010, 'COMT val108/158 met genotype affects neural but not cognitive processing in healthy individuals', Cerebral Cortex, vol. 20, no. 3, pp. 672-683. https://doi.org/10.1093/cercor/bhp132

COMT val108/158 met genotype affects neural but not cognitive processing in healthy individuals. / Dennis, Nancy A.; Need, Anna C.; Labar, Kevin S.; Waters-Metenier, Sheena; Cirulli, Elizabeth T.; Kragel, James; Goldstein, David B.; Cabeza, Roberto.

In: Cerebral Cortex, Vol. 20, No. 3, 01.03.2010, p. 672-683.

Research output: Contribution to journalArticle

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