TY - JOUR
T1 - Concentration and profile of 22 urinary polycyclic aromatic hydrocarbon metabolites in the US population
AU - Li, Zheng
AU - Sandau, Courtney D.
AU - Romanoff, Lovisa C.
AU - Caudill, Samuel P.
AU - Sjodin, Andreas
AU - Needham, Larry L.
AU - Patterson, Donald G.
N1 - Funding Information:
Funding source: This study is funded by the Centers for Disease Control and Prevention (CDC). Study design and sample collection were carried out by the National Center for Health Statistics (NCHS), CDC. Urine sample analysis was carried out by the Organic Toxicology Analytical Branch, Division of Laboratory Sciences, National Center for Environmental Health (NCEH), CDC. Appropriate informed consent has been obtained for the participation of human subjects in this survey.
PY - 2008/7
Y1 - 2008/7
N2 - Urinary monohydroxy polycyclic aromatic hydrocarbons (OH-PAHs) are a class of PAH metabolites used as biomarkers for assessing human exposure to PAHs. The Centers for Disease Control and Prevention's National Health and Nutrition Examination Survey (NHANES) uses OH-PAHs to establish reference range concentrations for the US population, and to set benchmarks for future epidemiologic and biomonitoring studies. For the years 2001 and 2002, 22 OH-PAH metabolites were measured in urine specimens from 2748 NHANES participants. Percentages of samples with detectable levels ranged from nearly 100% for metabolites of naphthalene, fluorene, phenanthrene, and pyrene, to less than 5% for metabolites from parent compounds with higher molecular weight such as chrysene, benzo[c]phenanthrene, and benz[a]anthracene. The geometric mean for 1-hydroxypyrene (1-PYR)-the most commonly used biomarker for PAH exposure-was 49.6 ng/L urine, or 46.4 ng/g creatinine. Children (ages 6-11) generally had higher levels than did adolescents (ages 12-19) or adults (ages 20 and older). Model-adjusted, least-square geometric means for 1-PYR were 87, 53 and 43 ng/L for children, adolescents (ages 12-19) and adults (ages 20 years and older), respectively. Log-transformed concentrations for major detectable OH-PAHs were significantly correlated with each other. The correlation coefficients between 1-PYR and other metabolites ranging from 0.17 to 0.63 support the use of 1-PYR as a useful surrogate representing PAH exposure.
AB - Urinary monohydroxy polycyclic aromatic hydrocarbons (OH-PAHs) are a class of PAH metabolites used as biomarkers for assessing human exposure to PAHs. The Centers for Disease Control and Prevention's National Health and Nutrition Examination Survey (NHANES) uses OH-PAHs to establish reference range concentrations for the US population, and to set benchmarks for future epidemiologic and biomonitoring studies. For the years 2001 and 2002, 22 OH-PAH metabolites were measured in urine specimens from 2748 NHANES participants. Percentages of samples with detectable levels ranged from nearly 100% for metabolites of naphthalene, fluorene, phenanthrene, and pyrene, to less than 5% for metabolites from parent compounds with higher molecular weight such as chrysene, benzo[c]phenanthrene, and benz[a]anthracene. The geometric mean for 1-hydroxypyrene (1-PYR)-the most commonly used biomarker for PAH exposure-was 49.6 ng/L urine, or 46.4 ng/g creatinine. Children (ages 6-11) generally had higher levels than did adolescents (ages 12-19) or adults (ages 20 and older). Model-adjusted, least-square geometric means for 1-PYR were 87, 53 and 43 ng/L for children, adolescents (ages 12-19) and adults (ages 20 years and older), respectively. Log-transformed concentrations for major detectable OH-PAHs were significantly correlated with each other. The correlation coefficients between 1-PYR and other metabolites ranging from 0.17 to 0.63 support the use of 1-PYR as a useful surrogate representing PAH exposure.
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U2 - 10.1016/j.envres.2008.01.013
DO - 10.1016/j.envres.2008.01.013
M3 - Article
C2 - 18313659
AN - SCOPUS:44649103908
VL - 107
SP - 320
EP - 331
JO - Environmental Research
JF - Environmental Research
SN - 0013-9351
IS - 3
ER -