Concentrations of unconjugated estrone, estradiol, androstenedione and testosterone in ovarian and peripheral venous plasma in women

The effects of steroid contraceptives

Judith Weisz, Charles W. Lloyd, Julia Lobotsky, Marcos Pupkin, Juan Zanartu, Juan Puga

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The concentrations of unconjugated estrone, estradiol, testosterone and androstenedione were measured in peripheral and ovarian venous plasma collected from 17 women treated with one of the following contraceptives: intramuscular medroxyprogesterone, oral chlormadinone or ethynodiol diacetate with mestranol. Estradiol in both ovarian and peripheral plasma was low; in all cases it was below the mean for 18 normal women. In ovarian venous plasma the levels of estrone were higher than those of estradiol in 7 of the 11 women treated with chlormadinone or ethynodiol and mestranol while in the 5 women treated with medroxyprogesterone estradiol was higher than estrone, as is found in untreated women. The principal change in the C19 steroids was a decreased concentration of androstenedione in ovarian venous plasma. This was especially evident in women treated with ethynodiol and mestranol. Testosterone levels were comparable to those of untreated subjects.

Original languageEnglish (US)
Pages (from-to)254-260
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume37
Issue number2
DOIs
StatePublished - Jan 1 1973

Fingerprint

Androstenedione
Estrone
Mestranol
Contraceptive Agents
Testosterone
Estradiol
Chlormadinone Acetate
Medroxyprogesterone
Steroids
Plasmas
Ethynodiol Diacetate
ethynodiol

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

@article{8e9da4c51cf54f63a4f78059946b5947,
title = "Concentrations of unconjugated estrone, estradiol, androstenedione and testosterone in ovarian and peripheral venous plasma in women: The effects of steroid contraceptives",
abstract = "The concentrations of unconjugated estrone, estradiol, testosterone and androstenedione were measured in peripheral and ovarian venous plasma collected from 17 women treated with one of the following contraceptives: intramuscular medroxyprogesterone, oral chlormadinone or ethynodiol diacetate with mestranol. Estradiol in both ovarian and peripheral plasma was low; in all cases it was below the mean for 18 normal women. In ovarian venous plasma the levels of estrone were higher than those of estradiol in 7 of the 11 women treated with chlormadinone or ethynodiol and mestranol while in the 5 women treated with medroxyprogesterone estradiol was higher than estrone, as is found in untreated women. The principal change in the C19 steroids was a decreased concentration of androstenedione in ovarian venous plasma. This was especially evident in women treated with ethynodiol and mestranol. Testosterone levels were comparable to those of untreated subjects.",
author = "Judith Weisz and Lloyd, {Charles W.} and Julia Lobotsky and Marcos Pupkin and Juan Zanartu and Juan Puga",
year = "1973",
month = "1",
day = "1",
doi = "10.1210/jcem-37-2-254",
language = "English (US)",
volume = "37",
pages = "254--260",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "2",

}

Concentrations of unconjugated estrone, estradiol, androstenedione and testosterone in ovarian and peripheral venous plasma in women : The effects of steroid contraceptives. / Weisz, Judith; Lloyd, Charles W.; Lobotsky, Julia; Pupkin, Marcos; Zanartu, Juan; Puga, Juan.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 37, No. 2, 01.01.1973, p. 254-260.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Concentrations of unconjugated estrone, estradiol, androstenedione and testosterone in ovarian and peripheral venous plasma in women

T2 - The effects of steroid contraceptives

AU - Weisz, Judith

AU - Lloyd, Charles W.

AU - Lobotsky, Julia

AU - Pupkin, Marcos

AU - Zanartu, Juan

AU - Puga, Juan

PY - 1973/1/1

Y1 - 1973/1/1

N2 - The concentrations of unconjugated estrone, estradiol, testosterone and androstenedione were measured in peripheral and ovarian venous plasma collected from 17 women treated with one of the following contraceptives: intramuscular medroxyprogesterone, oral chlormadinone or ethynodiol diacetate with mestranol. Estradiol in both ovarian and peripheral plasma was low; in all cases it was below the mean for 18 normal women. In ovarian venous plasma the levels of estrone were higher than those of estradiol in 7 of the 11 women treated with chlormadinone or ethynodiol and mestranol while in the 5 women treated with medroxyprogesterone estradiol was higher than estrone, as is found in untreated women. The principal change in the C19 steroids was a decreased concentration of androstenedione in ovarian venous plasma. This was especially evident in women treated with ethynodiol and mestranol. Testosterone levels were comparable to those of untreated subjects.

AB - The concentrations of unconjugated estrone, estradiol, testosterone and androstenedione were measured in peripheral and ovarian venous plasma collected from 17 women treated with one of the following contraceptives: intramuscular medroxyprogesterone, oral chlormadinone or ethynodiol diacetate with mestranol. Estradiol in both ovarian and peripheral plasma was low; in all cases it was below the mean for 18 normal women. In ovarian venous plasma the levels of estrone were higher than those of estradiol in 7 of the 11 women treated with chlormadinone or ethynodiol and mestranol while in the 5 women treated with medroxyprogesterone estradiol was higher than estrone, as is found in untreated women. The principal change in the C19 steroids was a decreased concentration of androstenedione in ovarian venous plasma. This was especially evident in women treated with ethynodiol and mestranol. Testosterone levels were comparable to those of untreated subjects.

UR - http://www.scopus.com/inward/record.url?scp=0015829697&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015829697&partnerID=8YFLogxK

U2 - 10.1210/jcem-37-2-254

DO - 10.1210/jcem-37-2-254

M3 - Article

VL - 37

SP - 254

EP - 260

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 2

ER -