Concerns with computational protein engineering programmes IPRO and OptMAVEn and metabolic pathway engineering programme optStoic

Research output: Contribution to journalArticlepeer-review

Abstract

It has become customary in engineering to require a modelling component in research endeavours. In addition, as the code for these models becomes more byzantine in complexity, it is difficult for reviewers and readers to discern their value and understand the underlying code. This opinion piece summarizes the negative experience of the author with the IPRO and OptMAVEn computational protein engineering models as well as problems with the optStoic metabolic pathway model. In our hands, these models often fail to predict reliable ways to engineer proteins and metabolic pathways.

Original languageEnglish (US)
Article number200173
JournalOpen biology
Volume11
Issue number2
DOIs
StatePublished - Feb 2 2021

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

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