Concise Synthesis of a Potential 5-Lipoxygenase Activating Protein (FLAP) Inhibitor and Its Analogs through Late-Stage Alkene Dicarbofunctionalization

Shekhar Kc, Roshan K. Dhungana, Vivek Aryal, Ramesh Giri

Research output: Contribution to journalArticle

Abstract

We report a five-step synthesis of the biologically important 1,1-diarylalkane 1, a potential 5-lipoxygenase activating protein (FLAP) inhibitor that was synthesized previously in 12 steps. In this synthesis, we apply a three-component alkene dicarbofunctionalization reaction as a key final step to assemble the potential FLAP inhibitor 1 from commercially available starting materials. In addition, we also report the synthesis of a variety of new analogs of the inhibitor 1 and its regioisomer.

Original languageEnglish (US)
Pages (from-to)1686-1694
Number of pages9
JournalOrganic Process Research and Development
Volume23
Issue number8
DOIs
StatePublished - Aug 16 2019

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5-Lipoxygenase-Activating Protein Inhibitors
5-Lipoxygenase-Activating Proteins
Alkenes
inhibitors
alkenes
analogs
proteins
synthesis

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

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abstract = "We report a five-step synthesis of the biologically important 1,1-diarylalkane 1, a potential 5-lipoxygenase activating protein (FLAP) inhibitor that was synthesized previously in 12 steps. In this synthesis, we apply a three-component alkene dicarbofunctionalization reaction as a key final step to assemble the potential FLAP inhibitor 1 from commercially available starting materials. In addition, we also report the synthesis of a variety of new analogs of the inhibitor 1 and its regioisomer.",
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Concise Synthesis of a Potential 5-Lipoxygenase Activating Protein (FLAP) Inhibitor and Its Analogs through Late-Stage Alkene Dicarbofunctionalization. / Kc, Shekhar; Dhungana, Roshan K.; Aryal, Vivek; Giri, Ramesh.

In: Organic Process Research and Development, Vol. 23, No. 8, 16.08.2019, p. 1686-1694.

Research output: Contribution to journalArticle

TY - JOUR

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AU - Giri, Ramesh

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