Concise Synthesis of a Potential 5-Lipoxygenase Activating Protein (FLAP) Inhibitor and Its Analogs through Late-Stage Alkene Dicarbofunctionalization

Shekhar Kc, Roshan K. Dhungana, Vivek Aryal, Ramesh Giri

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

We report a five-step synthesis of the biologically important 1,1-diarylalkane 1, a potential 5-lipoxygenase activating protein (FLAP) inhibitor that was synthesized previously in 12 steps. In this synthesis, we apply a three-component alkene dicarbofunctionalization reaction as a key final step to assemble the potential FLAP inhibitor 1 from commercially available starting materials. In addition, we also report the synthesis of a variety of new analogs of the inhibitor 1 and its regioisomer.

Original languageEnglish (US)
Pages (from-to)1686-1694
Number of pages9
JournalOrganic Process Research and Development
Volume23
Issue number8
DOIs
StatePublished - Aug 16 2019

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Organic Chemistry

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