Concurrent paclitaxel and radiation therapy for solid tumors

H. Choy, W. Akerley, Michael Glantz, H. Safran, S. Graziano, C. Chung

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

Background: Combination radiation and chemotherapy has an intuitive appeal for improving cancer treatment. Experimental results suggest that paclitaxel plus radiation might produce additive or synergistic effects. Methods: A series of phase I and II trials to test tolerance and begin to evaluate effectiveness were performed on patients with non-small cell lung cancer, high-grade astrocytic brain tumors, and pancreatic and gastric cancers. Results: Tolerance of the combined drug and radiation programs was generally good. Esophagitis was dose-limiting for the intrathoracic tumors. Hematologic toxicity was mild, but peripheral neuritis and cutaneous reactions were common. Conclusions: These trials show that paclitaxel plus concurrent radiation is feasible at the dose levels and schedules tested. Antitumor responses have been observed.

Original languageEnglish (US)
Pages (from-to)310-318
Number of pages9
JournalCancer Control
Volume3
Issue number4
DOIs
StatePublished - Jan 1 1996

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Paclitaxel
Radiotherapy
Radiation
Drug Tolerance
Background Radiation
Neuritis
Esophagitis
Radiation Tolerance
Combination Drug Therapy
Pancreatic Neoplasms
Non-Small Cell Lung Carcinoma
Brain Neoplasms
Stomach Neoplasms
Neoplasms
Appointments and Schedules
Skin
Therapeutics

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology

Cite this

Choy, H., Akerley, W., Glantz, M., Safran, H., Graziano, S., & Chung, C. (1996). Concurrent paclitaxel and radiation therapy for solid tumors. Cancer Control, 3(4), 310-318. https://doi.org/10.1177/107327489600300402
Choy, H. ; Akerley, W. ; Glantz, Michael ; Safran, H. ; Graziano, S. ; Chung, C. / Concurrent paclitaxel and radiation therapy for solid tumors. In: Cancer Control. 1996 ; Vol. 3, No. 4. pp. 310-318.
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Choy, H, Akerley, W, Glantz, M, Safran, H, Graziano, S & Chung, C 1996, 'Concurrent paclitaxel and radiation therapy for solid tumors', Cancer Control, vol. 3, no. 4, pp. 310-318. https://doi.org/10.1177/107327489600300402

Concurrent paclitaxel and radiation therapy for solid tumors. / Choy, H.; Akerley, W.; Glantz, Michael; Safran, H.; Graziano, S.; Chung, C.

In: Cancer Control, Vol. 3, No. 4, 01.01.1996, p. 310-318.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Concurrent paclitaxel and radiation therapy for solid tumors

AU - Choy, H.

AU - Akerley, W.

AU - Glantz, Michael

AU - Safran, H.

AU - Graziano, S.

AU - Chung, C.

PY - 1996/1/1

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AB - Background: Combination radiation and chemotherapy has an intuitive appeal for improving cancer treatment. Experimental results suggest that paclitaxel plus radiation might produce additive or synergistic effects. Methods: A series of phase I and II trials to test tolerance and begin to evaluate effectiveness were performed on patients with non-small cell lung cancer, high-grade astrocytic brain tumors, and pancreatic and gastric cancers. Results: Tolerance of the combined drug and radiation programs was generally good. Esophagitis was dose-limiting for the intrathoracic tumors. Hematologic toxicity was mild, but peripheral neuritis and cutaneous reactions were common. Conclusions: These trials show that paclitaxel plus concurrent radiation is feasible at the dose levels and schedules tested. Antitumor responses have been observed.

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