Conducting polymer microcontainers for biomedical applications

Milad Khorrami, Martin Antensteiner, Fatemeh Fallahianbijan, Ali Borhan, Mohammad Reza Abidian

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Advancement in the development of metallic-based implantable micro-scale bioelectronics has been limited by low signal to noise ratios and low charge injection at electrode-tissue interfaces. Further, implantable electrodes lose their long-term functionality because of unfavorable reactive tissue responses. Thus, substantial incentive exists to produce bioelectronics capable of delivering therapeutic compounds while improving electrical performance. Here, we have produced hollow poly(pyrrole) microcontainers (MCs) using poly(lactic-co-glycolic) acid (PLGA) as degradable templates. We demonstrate that the effective surface area of the electrode increases significantly as deposition charge density is increased, resulting in a 91% decrease in impedance and an 85% increase in charge storage capacity versus uncoated gold electrodes. We also developed an equivalent circuit model to quantify the effect of conducting polymer film growth on impedance. These MC-modified electrodes offer the potential to improve the electrical properties of implantable bioelectronics, as well as provide potential controlled release avenues for drug delivery applications.

Original languageEnglish (US)
Title of host publication2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Subtitle of host publicationSmarter Technology for a Healthier World, EMBC 2017 - Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1869-1872
Number of pages4
ISBN (Electronic)9781509028092
DOIs
StatePublished - Sep 13 2017
Event39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2017 - Jeju Island, Korea, Republic of
Duration: Jul 11 2017Jul 15 2017

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)1557-170X

Other

Other39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2017
CountryKorea, Republic of
CityJeju Island
Period7/11/177/15/17

Fingerprint

Conducting polymers
Polymers
Electrodes
Electric Impedance
Implanted Electrodes
Pyrroles
Tissue
Signal-To-Noise Ratio
Charge injection
Gold
Motivation
Film growth
Charge density
Drug delivery
Polymer films
Equivalent circuits
Signal to noise ratio
Electric properties
Injections
Growth

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

Khorrami, M., Antensteiner, M., Fallahianbijan, F., Borhan, A., & Abidian, M. R. (2017). Conducting polymer microcontainers for biomedical applications. In 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Smarter Technology for a Healthier World, EMBC 2017 - Proceedings (pp. 1869-1872). [8037211] (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2017.8037211
Khorrami, Milad ; Antensteiner, Martin ; Fallahianbijan, Fatemeh ; Borhan, Ali ; Abidian, Mohammad Reza. / Conducting polymer microcontainers for biomedical applications. 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Smarter Technology for a Healthier World, EMBC 2017 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2017. pp. 1869-1872 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).
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abstract = "Advancement in the development of metallic-based implantable micro-scale bioelectronics has been limited by low signal to noise ratios and low charge injection at electrode-tissue interfaces. Further, implantable electrodes lose their long-term functionality because of unfavorable reactive tissue responses. Thus, substantial incentive exists to produce bioelectronics capable of delivering therapeutic compounds while improving electrical performance. Here, we have produced hollow poly(pyrrole) microcontainers (MCs) using poly(lactic-co-glycolic) acid (PLGA) as degradable templates. We demonstrate that the effective surface area of the electrode increases significantly as deposition charge density is increased, resulting in a 91{\%} decrease in impedance and an 85{\%} increase in charge storage capacity versus uncoated gold electrodes. We also developed an equivalent circuit model to quantify the effect of conducting polymer film growth on impedance. These MC-modified electrodes offer the potential to improve the electrical properties of implantable bioelectronics, as well as provide potential controlled release avenues for drug delivery applications.",
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Khorrami, M, Antensteiner, M, Fallahianbijan, F, Borhan, A & Abidian, MR 2017, Conducting polymer microcontainers for biomedical applications. in 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Smarter Technology for a Healthier World, EMBC 2017 - Proceedings., 8037211, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, Institute of Electrical and Electronics Engineers Inc., pp. 1869-1872, 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2017, Jeju Island, Korea, Republic of, 7/11/17. https://doi.org/10.1109/EMBC.2017.8037211

Conducting polymer microcontainers for biomedical applications. / Khorrami, Milad; Antensteiner, Martin; Fallahianbijan, Fatemeh; Borhan, Ali; Abidian, Mohammad Reza.

2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Smarter Technology for a Healthier World, EMBC 2017 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2017. p. 1869-1872 8037211 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Khorrami M, Antensteiner M, Fallahianbijan F, Borhan A, Abidian MR. Conducting polymer microcontainers for biomedical applications. In 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Smarter Technology for a Healthier World, EMBC 2017 - Proceedings. Institute of Electrical and Electronics Engineers Inc. 2017. p. 1869-1872. 8037211. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/EMBC.2017.8037211