Conformational analysis of a covalently cross-linked Watson-Crick base pair model

Erik A. Jensen, Benjamin D. Allen, Yoshito Kishi, Daniel J. O'Leary

Research output: Contribution to journalArticle

Abstract

Low-temperature NMR experiments and molecular modeling have been used to characterize the conformational behavior of a covalently cross-linked DNA base pair model. The data suggest that Watson-Crick or reverse Watson-Crick hydrogen bonding geometries have similar energies and can interconvert at low temperatures. This low-temperature process involves rotation about the crosslink CH2{single bond}C(5′) (ψ) carbon-carbon bond, which is energetically preferred over the alternate CH2{single bond}N(3) (φ) carbon-nitrogen bond rotation.

Original languageEnglish (US)
Pages (from-to)5884-5887
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume18
Issue number22
DOIs
StatePublished - Nov 15 2008

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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