Conformationally restricted analogues designed for selective inhibition of GAR Tfase versus thymidylate synthase or dihydrofolate reductase

Dale L. Boger, Marc A. Labroli, Thomas H. Marsilje, Qing Jin, Michael P. Hedrick, Stephen J. Baker, Jae Hoon Shim, Stephen J. Benkovic

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

The synthesis and evaluation of a series of conformationally restricted analogues of 10-formyl-tetrahydrofolate as potential inhibitors of glycinamide ribonucleotide transformylase (GAR Tfase) or aminoimidazole carboxamide transformylase (AICAR Tfase) are reported. (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)1075-1086
Number of pages12
JournalBioorganic and Medicinal Chemistry
Volume8
Issue number5
DOIs
StatePublished - May 2000

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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