Conformations of immunoglobulin hypervariable regions

Cyrus Chothia, Arthur M. Lesk, Anna Tramontano, Michael Levitt, Sandra J. Smith-Gill, Gillian Air, Steven Sheriff, Eduardo A. Padlan, David Davies, William R. Tulip, Peter M. Colman, Silvia Spinelli, Pedro M. Alzari, Roberto J. Poljak

Research output: Contribution to journalArticlepeer-review

1044 Scopus citations

Abstract

On the basis of comparative studies of known antibody structures and sequences it has been argued that there is a small repertoire of main-chain conformations for at least five of the six hypervariable regions of antibodies, and that the particular conformation adopted is determined by a few key conserved residues. These hypotheses are now supported by reasonably successful predictions of the structures of most hypervariable regions of various antibodies, as revealed by comparison with their subsequently determined structures.

Original languageEnglish (US)
Pages (from-to)877-883
Number of pages7
JournalNature
Volume342
Issue number6252
DOIs
StatePublished - 1989

All Science Journal Classification (ASJC) codes

  • General

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