Conservation of ancestral haplotypes telomeric of HLA-A

G. K. Tay, S. K. Cattley, Michael J. Chorney, P. N. Hollingsworth, M. P. Roth, R. L. Dawkins, C. S. Witt

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Genes that predispose to haemochromatosis are thought to be located within the several megabases telomeric of HLA-A. Further recombinant mapping has been used previously to map susceptibility genes for diseases such as insulin-dependent diabetes mellitus, myasthenia gravis and cystic fibrosis, and should be useful in relation to haemochromatosis. However, this method requires the recognition of ancestral haplotypes within the susceptibility region. Using a panel of six microsatellite markers from this region (MOG A, MOG B, MOG C, D6S464, D6S306 and D6S105), we show that ancestral haplotypes extend telomeric of HLA-A, at least as far as D6S105. Nine of 14 haplotypes carrying HLA-B7 and HLA-A3 shared the same microsatellite alleles between HLA-A and at least D6S105. Similarly, nine of 10 haplotypes sharing HLA-B8 and HLA-A1 shared the same microsatellite alleles, although a different set to those with HLA-B7 and HLA-A3. Haplotypes representing historical recombination events were also identified. These two findings demonstrate that recombinant mapping may be applicable to the mapping of disease genes in this region.

Original languageEnglish (US)
Pages (from-to)275-285
Number of pages11
JournalEuropean Journal of Immunogenetics
Volume24
Issue number4
DOIs
StatePublished - Jan 1 1997

Fingerprint

HLA-A Antigens
Haplotypes
HLA-A3 Antigen
HLA-B7 Antigen
Microsatellite Repeats
Hemochromatosis
HLA-A1 Antigen
Alleles
HLA-B8 Antigen
Chromosome Mapping
Myasthenia Gravis
Disease Susceptibility
Type 1 Diabetes Mellitus
Cystic Fibrosis
Genetic Recombination
Genes

All Science Journal Classification (ASJC) codes

  • Immunology
  • Genetics

Cite this

Tay, G. K., Cattley, S. K., Chorney, M. J., Hollingsworth, P. N., Roth, M. P., Dawkins, R. L., & Witt, C. S. (1997). Conservation of ancestral haplotypes telomeric of HLA-A. European Journal of Immunogenetics, 24(4), 275-285. https://doi.org/10.1111/j.1365-2370.1997.tb00021.x
Tay, G. K. ; Cattley, S. K. ; Chorney, Michael J. ; Hollingsworth, P. N. ; Roth, M. P. ; Dawkins, R. L. ; Witt, C. S. / Conservation of ancestral haplotypes telomeric of HLA-A. In: European Journal of Immunogenetics. 1997 ; Vol. 24, No. 4. pp. 275-285.
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Tay, GK, Cattley, SK, Chorney, MJ, Hollingsworth, PN, Roth, MP, Dawkins, RL & Witt, CS 1997, 'Conservation of ancestral haplotypes telomeric of HLA-A', European Journal of Immunogenetics, vol. 24, no. 4, pp. 275-285. https://doi.org/10.1111/j.1365-2370.1997.tb00021.x

Conservation of ancestral haplotypes telomeric of HLA-A. / Tay, G. K.; Cattley, S. K.; Chorney, Michael J.; Hollingsworth, P. N.; Roth, M. P.; Dawkins, R. L.; Witt, C. S.

In: European Journal of Immunogenetics, Vol. 24, No. 4, 01.01.1997, p. 275-285.

Research output: Contribution to journalArticle

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AU - Chorney, Michael J.

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AU - Dawkins, R. L.

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Tay GK, Cattley SK, Chorney MJ, Hollingsworth PN, Roth MP, Dawkins RL et al. Conservation of ancestral haplotypes telomeric of HLA-A. European Journal of Immunogenetics. 1997 Jan 1;24(4):275-285. https://doi.org/10.1111/j.1365-2370.1997.tb00021.x