Conserved regulatory element involved in the early onset of Hoxb6 gene expression

Diko Becker, Zhiling Jiang, Patrick Knödler, Amos S. Deinard, Roland Eid, Kenneth K. Kidd, Cooduvalli S. Shashikant, Frank H. Ruddle, Klaus Schughart

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

We have identified a 338 bp DNA fragment, the lateral plate mesoderm (LPM) enhancer, that is highly conserved between mouse and human. The LPM enhancer directs gene expression into the posterior lateral plate mesoderm and hindgut endoderm at early stages of development. By reporter gene analysis in transgenic mice, we demonstrate that both mouse and human DNA sequences possess similar enhancer activity. The expression patterns of the transgene and Hoxb6 during early stages of mouse development are identical, suggesting that the LPM enhancer is involved in the initial activation of Hoxb6 gene expression in posterior regions of mammalian embryos.

Original languageEnglish (US)
Pages (from-to)73-81
Number of pages9
JournalDevelopmental Dynamics
Volume205
Issue number1
DOIs
StatePublished - Jan 1996

All Science Journal Classification (ASJC) codes

  • Developmental Biology

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