Considering a potential role of linalool as a mood stabilizer for bipolar disorder

Kate Levenberg, Wade Edris, Martha Levine, Daniel R. George

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Epidemiologic studies suggest that the lifetime prevalence of bipolar spectrum disorders ranges from 2.8 to 6.5 percent of the population. To decrease morbidity and mortality associated with disease progression, pharmacologic intervention is indicated for the majority of these patients. While a number of effective treatment regimens exist, many conventional medications have significant side effect profiles that adversely impact pa-tients’ short and long-term well-being. It is thus important to continue advancing and improving therapeutic options available to patients. This paper reviews the limitations of current treatments and examines the chemical compound Linalool, an alcohol found in many plant species, that may serve as an effective mood stabilizer. While relatively little is known about Linalool and bipolar disorder, the compound has been shown to have anti-epileptic, anti-inflammatory, anxiolytic, anti-depressive, and neurotrophic effects, with mechanisms that are com-parable to current bipolar disorder treatment options.

Original languageEnglish (US)
Pages (from-to)5128-5133
Number of pages6
JournalCurrent Pharmaceutical Design
Volume26
Issue number40
DOIs
StatePublished - 2020

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

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