Consortium biology in immunology: The perspective from the Immunological Genome Project

Christophe Benoist, Lewis Lanier, Miriam Merad, Diane Mathis, Jeff Ericson, Michio Painter, Scott Davis, Catherine Laplace, Gordon Hyatt, Henry Paik, Katie Rothamel, Richard Cruse, Graeme Doran, Tracy Heng, Natasha Asinovski, Adriana Ortiz-Lopes, Ayla Ergun, Daniel Gray, Ei Wakamatsu, Jonathan HillMichael Mingueneau, Daniela Cipolletta, Hideyuki Yoshida, Nadia Cohen, Edy Kim, Patrick Brennan, Lydia Lynch, Michael Brenner, James Costello, Jim J. Collins, David Blair, Michael Dustin, Jamie Knell, Edward Yang, Adam Best, Laura Shaw, Andrew Doedens, Ananda Goldrath, Susan Shinton, Yan Zhou, Randy Hardy, Vladimir Jojic, Sara Mostafavi, Daphne Koller, Radu Jianu, David Laidlaw, Natalie Bezman, Joseph Sun, Yanan Zhu, Deborah Hendricks, Yosuke Kamimura, Gundula Min-Oo, Deborah Hendricks, Maelig Morvan, Yosuke Kamimura, Tsukasa Nabekura, Viola Lam, Charles Kim, Melanie Greter, Julie Helft, Andrew Chow, Milena Bogunovic, Arthur Mortha, Jeremy Price, Daigo Hashimoto, Jennifer Miller, Priyanka Sathe, Aleksey Chudnovskiy, Yonit Lavin, Juliana Idoyaga, Emmanuel Gautier, Claudia Jakubzick, June D'Angelo, Gwendolyn Randolph, Tal Shay, Aviv Regev, Roi Gazit, Derrick Rossi, Taras Kreslawsky, Harald von Bohmer, Angelique Bellemare-Pelletier, Kutlu Elpek, Lotte Spelv, Anne Fletcher, Deepali Malhotra, Viviana Cremasco, Shannon Turley, Francis Kim, Tata Nageswara Rao, Amy Wagers

Research output: Contribution to journalReview article

21 Citations (Scopus)

Abstract

Although the field has a long collaborative tradition, immunology has made less use than genetics of 'consortium biology', wherein groups of investigators together tackle large integrated questions or problems. However, immunology is naturally suited to large-scale integrative and systems-level approaches, owing to the multicellular and adaptive nature of the cells it encompasses. Here, we discuss the value and drawbacks of this organization of research, in the context of the long-running 'big science' debate, and consider the opportunities that may exist for the immunology community. We position this analysis in light of our own experience, both positive and negative, as participants of the Immunological Genome Project.

Original languageEnglish (US)
Pages (from-to)734-740
Number of pages7
JournalNature Reviews Immunology
Volume12
Issue number10
DOIs
StatePublished - Oct 1 2012

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All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Benoist, C., Lanier, L., Merad, M., Mathis, D., Ericson, J., Painter, M., ... Wagers, A. (2012). Consortium biology in immunology: The perspective from the Immunological Genome Project. Nature Reviews Immunology, 12(10), 734-740. https://doi.org/10.1038/nri3300
Benoist, Christophe ; Lanier, Lewis ; Merad, Miriam ; Mathis, Diane ; Ericson, Jeff ; Painter, Michio ; Davis, Scott ; Laplace, Catherine ; Hyatt, Gordon ; Paik, Henry ; Rothamel, Katie ; Cruse, Richard ; Doran, Graeme ; Heng, Tracy ; Asinovski, Natasha ; Ortiz-Lopes, Adriana ; Ergun, Ayla ; Gray, Daniel ; Wakamatsu, Ei ; Hill, Jonathan ; Mingueneau, Michael ; Cipolletta, Daniela ; Yoshida, Hideyuki ; Cohen, Nadia ; Kim, Edy ; Brennan, Patrick ; Lynch, Lydia ; Brenner, Michael ; Costello, James ; Collins, Jim J. ; Blair, David ; Dustin, Michael ; Knell, Jamie ; Yang, Edward ; Best, Adam ; Shaw, Laura ; Doedens, Andrew ; Goldrath, Ananda ; Shinton, Susan ; Zhou, Yan ; Hardy, Randy ; Jojic, Vladimir ; Mostafavi, Sara ; Koller, Daphne ; Jianu, Radu ; Laidlaw, David ; Bezman, Natalie ; Sun, Joseph ; Zhu, Yanan ; Hendricks, Deborah ; Kamimura, Yosuke ; Min-Oo, Gundula ; Hendricks, Deborah ; Morvan, Maelig ; Kamimura, Yosuke ; Nabekura, Tsukasa ; Lam, Viola ; Kim, Charles ; Greter, Melanie ; Helft, Julie ; Chow, Andrew ; Bogunovic, Milena ; Mortha, Arthur ; Price, Jeremy ; Hashimoto, Daigo ; Miller, Jennifer ; Sathe, Priyanka ; Chudnovskiy, Aleksey ; Lavin, Yonit ; Idoyaga, Juliana ; Gautier, Emmanuel ; Jakubzick, Claudia ; D'Angelo, June ; Randolph, Gwendolyn ; Shay, Tal ; Regev, Aviv ; Gazit, Roi ; Rossi, Derrick ; Kreslawsky, Taras ; von Bohmer, Harald ; Bellemare-Pelletier, Angelique ; Elpek, Kutlu ; Spelv, Lotte ; Fletcher, Anne ; Malhotra, Deepali ; Cremasco, Viviana ; Turley, Shannon ; Kim, Francis ; Nageswara Rao, Tata ; Wagers, Amy. / Consortium biology in immunology : The perspective from the Immunological Genome Project. In: Nature Reviews Immunology. 2012 ; Vol. 12, No. 10. pp. 734-740.
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Benoist, C, Lanier, L, Merad, M, Mathis, D, Ericson, J, Painter, M, Davis, S, Laplace, C, Hyatt, G, Paik, H, Rothamel, K, Cruse, R, Doran, G, Heng, T, Asinovski, N, Ortiz-Lopes, A, Ergun, A, Gray, D, Wakamatsu, E, Hill, J, Mingueneau, M, Cipolletta, D, Yoshida, H, Cohen, N, Kim, E, Brennan, P, Lynch, L, Brenner, M, Costello, J, Collins, JJ, Blair, D, Dustin, M, Knell, J, Yang, E, Best, A, Shaw, L, Doedens, A, Goldrath, A, Shinton, S, Zhou, Y, Hardy, R, Jojic, V, Mostafavi, S, Koller, D, Jianu, R, Laidlaw, D, Bezman, N, Sun, J, Zhu, Y, Hendricks, D, Kamimura, Y, Min-Oo, G, Hendricks, D, Morvan, M, Kamimura, Y, Nabekura, T, Lam, V, Kim, C, Greter, M, Helft, J, Chow, A, Bogunovic, M, Mortha, A, Price, J, Hashimoto, D, Miller, J, Sathe, P, Chudnovskiy, A, Lavin, Y, Idoyaga, J, Gautier, E, Jakubzick, C, D'Angelo, J, Randolph, G, Shay, T, Regev, A, Gazit, R, Rossi, D, Kreslawsky, T, von Bohmer, H, Bellemare-Pelletier, A, Elpek, K, Spelv, L, Fletcher, A, Malhotra, D, Cremasco, V, Turley, S, Kim, F, Nageswara Rao, T & Wagers, A 2012, 'Consortium biology in immunology: The perspective from the Immunological Genome Project', Nature Reviews Immunology, vol. 12, no. 10, pp. 734-740. https://doi.org/10.1038/nri3300

Consortium biology in immunology : The perspective from the Immunological Genome Project. / Benoist, Christophe; Lanier, Lewis; Merad, Miriam; Mathis, Diane; Ericson, Jeff; Painter, Michio; Davis, Scott; Laplace, Catherine; Hyatt, Gordon; Paik, Henry; Rothamel, Katie; Cruse, Richard; Doran, Graeme; Heng, Tracy; Asinovski, Natasha; Ortiz-Lopes, Adriana; Ergun, Ayla; Gray, Daniel; Wakamatsu, Ei; Hill, Jonathan; Mingueneau, Michael; Cipolletta, Daniela; Yoshida, Hideyuki; Cohen, Nadia; Kim, Edy; Brennan, Patrick; Lynch, Lydia; Brenner, Michael; Costello, James; Collins, Jim J.; Blair, David; Dustin, Michael; Knell, Jamie; Yang, Edward; Best, Adam; Shaw, Laura; Doedens, Andrew; Goldrath, Ananda; Shinton, Susan; Zhou, Yan; Hardy, Randy; Jojic, Vladimir; Mostafavi, Sara; Koller, Daphne; Jianu, Radu; Laidlaw, David; Bezman, Natalie; Sun, Joseph; Zhu, Yanan; Hendricks, Deborah; Kamimura, Yosuke; Min-Oo, Gundula; Hendricks, Deborah; Morvan, Maelig; Kamimura, Yosuke; Nabekura, Tsukasa; Lam, Viola; Kim, Charles; Greter, Melanie; Helft, Julie; Chow, Andrew; Bogunovic, Milena; Mortha, Arthur; Price, Jeremy; Hashimoto, Daigo; Miller, Jennifer; Sathe, Priyanka; Chudnovskiy, Aleksey; Lavin, Yonit; Idoyaga, Juliana; Gautier, Emmanuel; Jakubzick, Claudia; D'Angelo, June; Randolph, Gwendolyn; Shay, Tal; Regev, Aviv; Gazit, Roi; Rossi, Derrick; Kreslawsky, Taras; von Bohmer, Harald; Bellemare-Pelletier, Angelique; Elpek, Kutlu; Spelv, Lotte; Fletcher, Anne; Malhotra, Deepali; Cremasco, Viviana; Turley, Shannon; Kim, Francis; Nageswara Rao, Tata; Wagers, Amy.

In: Nature Reviews Immunology, Vol. 12, No. 10, 01.10.2012, p. 734-740.

Research output: Contribution to journalReview article

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T1 - Consortium biology in immunology

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AU - Benoist, Christophe

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AU - Merad, Miriam

AU - Mathis, Diane

AU - Ericson, Jeff

AU - Painter, Michio

AU - Davis, Scott

AU - Laplace, Catherine

AU - Hyatt, Gordon

AU - Paik, Henry

AU - Rothamel, Katie

AU - Cruse, Richard

AU - Doran, Graeme

AU - Heng, Tracy

AU - Asinovski, Natasha

AU - Ortiz-Lopes, Adriana

AU - Ergun, Ayla

AU - Gray, Daniel

AU - Wakamatsu, Ei

AU - Hill, Jonathan

AU - Mingueneau, Michael

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AU - Yoshida, Hideyuki

AU - Cohen, Nadia

AU - Kim, Edy

AU - Brennan, Patrick

AU - Lynch, Lydia

AU - Brenner, Michael

AU - Costello, James

AU - Collins, Jim J.

AU - Blair, David

AU - Dustin, Michael

AU - Knell, Jamie

AU - Yang, Edward

AU - Best, Adam

AU - Shaw, Laura

AU - Doedens, Andrew

AU - Goldrath, Ananda

AU - Shinton, Susan

AU - Zhou, Yan

AU - Hardy, Randy

AU - Jojic, Vladimir

AU - Mostafavi, Sara

AU - Koller, Daphne

AU - Jianu, Radu

AU - Laidlaw, David

AU - Bezman, Natalie

AU - Sun, Joseph

AU - Zhu, Yanan

AU - Hendricks, Deborah

AU - Kamimura, Yosuke

AU - Min-Oo, Gundula

AU - Hendricks, Deborah

AU - Morvan, Maelig

AU - Kamimura, Yosuke

AU - Nabekura, Tsukasa

AU - Lam, Viola

AU - Kim, Charles

AU - Greter, Melanie

AU - Helft, Julie

AU - Chow, Andrew

AU - Bogunovic, Milena

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AU - Price, Jeremy

AU - Hashimoto, Daigo

AU - Miller, Jennifer

AU - Sathe, Priyanka

AU - Chudnovskiy, Aleksey

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AU - Jakubzick, Claudia

AU - D'Angelo, June

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AU - Regev, Aviv

AU - Gazit, Roi

AU - Rossi, Derrick

AU - Kreslawsky, Taras

AU - von Bohmer, Harald

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AU - Elpek, Kutlu

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AU - Fletcher, Anne

AU - Malhotra, Deepali

AU - Cremasco, Viviana

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Benoist C, Lanier L, Merad M, Mathis D, Ericson J, Painter M et al. Consortium biology in immunology: The perspective from the Immunological Genome Project. Nature Reviews Immunology. 2012 Oct 1;12(10):734-740. https://doi.org/10.1038/nri3300