This paper presents an efficient method for constructing aligned blocks (i.e., gap-free multiple alignments) from a set of pairwise alignments. The method is more sensitive than some earlier block-constructing methods for detecting conserved sequence regions. The technique is applied to analyze conserved regions in protein prenyltransferases and to detect regulatory elements in the 5′ flank of the β-globin gene.
All Science Journal Classification (ASJC) codes
- Modeling and Simulation
- Molecular Biology
- Computational Mathematics
- Computational Theory and Mathematics