Construction of the azzocane (azacyclooctane) moiety of the lycopodium alkaloid lycopladine h via an intramolecular hydroaminomethylation strategy

Joshua R. Sacher, Steven M. Weinreb

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

An efficient synthetic strategy has been developed for annulation of an azocane ring onto a bicyclo[2.2.2]octane scaffold via an intramolecular hydroaminomethylation protocol to generate an advanced intermediate bearing three of the four rings of the structurally unique Lycopodium alkaloid lycopladine H (1).

Original languageEnglish (US)
Pages (from-to)2172-2175
Number of pages4
JournalOrganic Letters
Volume14
Issue number8
DOIs
StatePublished - Apr 20 2012

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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