Abstract
We present a highly adaptable design platform for multi-responsive, multilayered composite nanoparticles (MC-NPs) with fine-tunable functional layers. A flexible disulfide-linked nanogel template is obtained by a controlled in-situ gelation method, enabling a high degree of control over each successive layer. From this template, we optimize “smart” biomaterials with biofunctional surfaces, tunable drug release kinetics, and magnetic or pH-responsive functionality, fabricated into MC-NPs for targeted drug release and periosteum-mimetic structures for controlled rhBMP-2 release towards bone tissue formation in-vivo. Such a versatile platform for the design of MC-NPs is a powerful tool that shows considerable therapeutic potential in clinical fields such as oncology and orthopedics.
Original language | English (US) |
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Pages (from-to) | 87-96 |
Number of pages | 10 |
Journal | Bioactive Materials |
Volume | 3 |
Issue number | 1 |
DOIs | |
State | Published - Mar 2018 |
All Science Journal Classification (ASJC) codes
- Biotechnology
- Biomaterials
- Biomedical Engineering