Abstract
We present a highly adaptable design platform for multi-responsive, multilayered composite nanoparticles (MC-NPs) with fine-tunable functional layers. A flexible disulfide-linked nanogel template is obtained by a controlled in-situ gelation method, enabling a high degree of control over each successive layer. From this template, we optimize “smart” biomaterials with biofunctional surfaces, tunable drug release kinetics, and magnetic or pH-responsive functionality, fabricated into MC-NPs for targeted drug release and periosteum-mimetic structures for controlled rhBMP-2 release towards bone tissue formation in-vivo. Such a versatile platform for the design of MC-NPs is a powerful tool that shows considerable therapeutic potential in clinical fields such as oncology and orthopedics.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 87-96 |
| Number of pages | 10 |
| Journal | Bioactive Materials |
| Volume | 3 |
| Issue number | 1 |
| DOIs | |
| State | Published - Mar 2018 |
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All Science Journal Classification (ASJC) codes
- Biotechnology
- Biomaterials
- Biomedical Engineering
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Construction of versatile multilayered composite nanoparticles from a customized nanogel template. / Zhang, Jian; Jia, Jinpeng; Kim, Jimin P.; Yang, Fei; Wang, Xing; Shen, Hong; Xu, Sijia; Yang, Jian; Wu, Decheng.
In: Bioactive Materials, Vol. 3, No. 1, 03.2018, p. 87-96.Research output: Contribution to journal › Article
TY - JOUR
T1 - Construction of versatile multilayered composite nanoparticles from a customized nanogel template
AU - Zhang, Jian
AU - Jia, Jinpeng
AU - Kim, Jimin P.
AU - Yang, Fei
AU - Wang, Xing
AU - Shen, Hong
AU - Xu, Sijia
AU - Yang, Jian
AU - Wu, Decheng
PY - 2018/3
Y1 - 2018/3
N2 - We present a highly adaptable design platform for multi-responsive, multilayered composite nanoparticles (MC-NPs) with fine-tunable functional layers. A flexible disulfide-linked nanogel template is obtained by a controlled in-situ gelation method, enabling a high degree of control over each successive layer. From this template, we optimize “smart” biomaterials with biofunctional surfaces, tunable drug release kinetics, and magnetic or pH-responsive functionality, fabricated into MC-NPs for targeted drug release and periosteum-mimetic structures for controlled rhBMP-2 release towards bone tissue formation in-vivo. Such a versatile platform for the design of MC-NPs is a powerful tool that shows considerable therapeutic potential in clinical fields such as oncology and orthopedics.
AB - We present a highly adaptable design platform for multi-responsive, multilayered composite nanoparticles (MC-NPs) with fine-tunable functional layers. A flexible disulfide-linked nanogel template is obtained by a controlled in-situ gelation method, enabling a high degree of control over each successive layer. From this template, we optimize “smart” biomaterials with biofunctional surfaces, tunable drug release kinetics, and magnetic or pH-responsive functionality, fabricated into MC-NPs for targeted drug release and periosteum-mimetic structures for controlled rhBMP-2 release towards bone tissue formation in-vivo. Such a versatile platform for the design of MC-NPs is a powerful tool that shows considerable therapeutic potential in clinical fields such as oncology and orthopedics.
UR - http://www.scopus.com/inward/record.url?scp=85036566411&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85036566411&partnerID=8YFLogxK
U2 - 10.1016/j.bioactmat.2017.06.003
DO - 10.1016/j.bioactmat.2017.06.003
M3 - Article
C2 - 29744445
AN - SCOPUS:85036566411
VL - 3
SP - 87
EP - 96
JO - Bioactive Materials
JF - Bioactive Materials
SN - 2452-199X
IS - 1
ER -