Construction of versatile multilayered composite nanoparticles from a customized nanogel template

Jian Zhang, Jinpeng Jia, Jimin P. Kim, Fei Yang, Xing Wang, Hong Shen, Sijia Xu, Jian Yang, Decheng Wu

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We present a highly adaptable design platform for multi-responsive, multilayered composite nanoparticles (MC-NPs) with fine-tunable functional layers. A flexible disulfide-linked nanogel template is obtained by a controlled in-situ gelation method, enabling a high degree of control over each successive layer. From this template, we optimize “smart” biomaterials with biofunctional surfaces, tunable drug release kinetics, and magnetic or pH-responsive functionality, fabricated into MC-NPs for targeted drug release and periosteum-mimetic structures for controlled rhBMP-2 release towards bone tissue formation in-vivo. Such a versatile platform for the design of MC-NPs is a powerful tool that shows considerable therapeutic potential in clinical fields such as oncology and orthopedics.

Original languageEnglish (US)
Pages (from-to)87-96
Number of pages10
JournalBioactive Materials
Volume3
Issue number1
DOIs
StatePublished - Mar 2018

Fingerprint

Nanoparticles
Composite materials
Periosteum
Oncology
Orthopedics
Biocompatible Materials
Gelation
Osteogenesis
Biomaterials
Disulfides
Pharmaceutical Preparations
Bone
Pharmacokinetics
Tissue
Bone and Bones
Kinetics
NanoGel
Drug Liberation
Therapeutics

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biomaterials
  • Biomedical Engineering

Cite this

Zhang, Jian ; Jia, Jinpeng ; Kim, Jimin P. ; Yang, Fei ; Wang, Xing ; Shen, Hong ; Xu, Sijia ; Yang, Jian ; Wu, Decheng. / Construction of versatile multilayered composite nanoparticles from a customized nanogel template. In: Bioactive Materials. 2018 ; Vol. 3, No. 1. pp. 87-96.
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Construction of versatile multilayered composite nanoparticles from a customized nanogel template. / Zhang, Jian; Jia, Jinpeng; Kim, Jimin P.; Yang, Fei; Wang, Xing; Shen, Hong; Xu, Sijia; Yang, Jian; Wu, Decheng.

In: Bioactive Materials, Vol. 3, No. 1, 03.2018, p. 87-96.

Research output: Contribution to journalArticle

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AU - Zhang, Jian

AU - Jia, Jinpeng

AU - Kim, Jimin P.

AU - Yang, Fei

AU - Wang, Xing

AU - Shen, Hong

AU - Xu, Sijia

AU - Yang, Jian

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