Construction of versatile multilayered composite nanoparticles from a customized nanogel template

Jian Zhang; Jinpeng Jia; Jimin P. Kim; Fei Yang; Xing Wang; Hong Shen; Sijia Xu; Jian Yang; Decheng Wu

doi:10.1016/j.bioactmat.2017.06.003

Construction of versatile multilayered composite nanoparticles from a customized nanogel template

Jian Zhang, Jinpeng Jia, Jimin P. Kim, Fei Yang, Xing Wang, Hong Shen, Sijia Xu, Jian Yang, Decheng Wu

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

We present a highly adaptable design platform for multi-responsive, multilayered composite nanoparticles (MC-NPs) with fine-tunable functional layers. A flexible disulfide-linked nanogel template is obtained by a controlled in-situ gelation method, enabling a high degree of control over each successive layer. From this template, we optimize “smart” biomaterials with biofunctional surfaces, tunable drug release kinetics, and magnetic or pH-responsive functionality, fabricated into MC-NPs for targeted drug release and periosteum-mimetic structures for controlled rhBMP-2 release towards bone tissue formation in-vivo. Such a versatile platform for the design of MC-NPs is a powerful tool that shows considerable therapeutic potential in clinical fields such as oncology and orthopedics.

Original language	English (US)
Pages (from-to)	87-96
Number of pages	10
Journal	Bioactive Materials
Volume	3
Issue number	1
DOIs	https://doi.org/10.1016/j.bioactmat.2017.06.003
State	Published - Mar 2018

All Science Journal Classification (ASJC) codes

Biotechnology
Biomaterials
Biomedical Engineering

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@article{f828719a03a0401db34ec48d71204254,

title = "Construction of versatile multilayered composite nanoparticles from a customized nanogel template",

abstract = "We present a highly adaptable design platform for multi-responsive, multilayered composite nanoparticles (MC-NPs) with fine-tunable functional layers. A flexible disulfide-linked nanogel template is obtained by a controlled in-situ gelation method, enabling a high degree of control over each successive layer. From this template, we optimize “smart” biomaterials with biofunctional surfaces, tunable drug release kinetics, and magnetic or pH-responsive functionality, fabricated into MC-NPs for targeted drug release and periosteum-mimetic structures for controlled rhBMP-2 release towards bone tissue formation in-vivo. Such a versatile platform for the design of MC-NPs is a powerful tool that shows considerable therapeutic potential in clinical fields such as oncology and orthopedics.",

author = "Jian Zhang and Jinpeng Jia and Kim, {Jimin P.} and Fei Yang and Xing Wang and Hong Shen and Sijia Xu and Jian Yang and Decheng Wu",

note = "Funding Information: We gratefully acknowledge MOST ( 2014CB932200 ), “Young Thousand Talents Program”, and NSFC ( 21674120 , 81630056 , 21504096 , 51573195 , 21474115 and 21174147 ) for financial support. ",

year = "2018",

month = mar,

doi = "10.1016/j.bioactmat.2017.06.003",

language = "English (US)",

volume = "3",

pages = "87--96",

journal = "Bioactive Materials",

issn = "2452-199X",

publisher = "KeAi Communications Co",

number = "1",

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TY - JOUR

T1 - Construction of versatile multilayered composite nanoparticles from a customized nanogel template

AU - Zhang, Jian

AU - Jia, Jinpeng

AU - Kim, Jimin P.

AU - Yang, Fei

AU - Wang, Xing

AU - Shen, Hong

AU - Xu, Sijia

AU - Yang, Jian

AU - Wu, Decheng

N1 - Funding Information: We gratefully acknowledge MOST ( 2014CB932200 ), “Young Thousand Talents Program”, and NSFC ( 21674120 , 81630056 , 21504096 , 51573195 , 21474115 and 21174147 ) for financial support.

PY - 2018/3

Y1 - 2018/3

N2 - We present a highly adaptable design platform for multi-responsive, multilayered composite nanoparticles (MC-NPs) with fine-tunable functional layers. A flexible disulfide-linked nanogel template is obtained by a controlled in-situ gelation method, enabling a high degree of control over each successive layer. From this template, we optimize “smart” biomaterials with biofunctional surfaces, tunable drug release kinetics, and magnetic or pH-responsive functionality, fabricated into MC-NPs for targeted drug release and periosteum-mimetic structures for controlled rhBMP-2 release towards bone tissue formation in-vivo. Such a versatile platform for the design of MC-NPs is a powerful tool that shows considerable therapeutic potential in clinical fields such as oncology and orthopedics.

AB - We present a highly adaptable design platform for multi-responsive, multilayered composite nanoparticles (MC-NPs) with fine-tunable functional layers. A flexible disulfide-linked nanogel template is obtained by a controlled in-situ gelation method, enabling a high degree of control over each successive layer. From this template, we optimize “smart” biomaterials with biofunctional surfaces, tunable drug release kinetics, and magnetic or pH-responsive functionality, fabricated into MC-NPs for targeted drug release and periosteum-mimetic structures for controlled rhBMP-2 release towards bone tissue formation in-vivo. Such a versatile platform for the design of MC-NPs is a powerful tool that shows considerable therapeutic potential in clinical fields such as oncology and orthopedics.

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JO - Bioactive Materials

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