Contact Dermatitis Associated with Skin Cleansers: Retrospective Analysis of North American Contact Dermatitis Group Data 2000-2014

Erin M. Warshaw, Molly C. Goodier, Joel G. Dekoven, Howard I. Maibach, James S. Taylor, Denis Sasseville, Donald V. Belsito, Joseph F. Fowler, Anthony F. Fransway, Vincent A. Deleo, James Marks, Melanie D. Pratt, Toby Mathias, Matthew J. Zirwas, Kathryn A. Zug

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background There is limited information regarding contact dermatitis (CD) associated with skin cleansers (SCs). Objective The aim of the study was to evaluate the prevalence of allergic patch test (APT) reactions and irritant CD (ICD) associated with SCs. Methods A retrospective cross-sectional analysis was performed using North American Contact Dermatitis Group data, 2000-2014. Results Of 32,945 tested patients, 1069 (3.24%) had either APT reaction or ICD associated with SCs. Of these, 692 (64.7%) had APT reaction only, 350 (32.7%) had ICD only, and 27 (2.5%) had both. Individuals with APT reaction and/or ICD were more likely to have occupationally related skin disease (relative risk [RR] = 3.8 [95% confidence interval {CI} = 3.3-4.5] for APT reaction and 10.0 [95% CI = 8.2-12.2] for ICD, respectively, P < 0.0001). As compared with those without APT reaction to SC, individuals with APT reaction had significantly higher frequencies of hand (RR = 2.4 [95% CI = 2.1-2.7]) and arm dermatitis (RR = 1.3 [95% CI = 1.1-1.6], P ≤ 0.001). Irritant CD was strongly associated with hand dermatitis (RR = 6.2 [95% CI = 5.2-7.3], P < 0.0001). More than 50 allergens were associated with SCs including quaternium-15 (11.2%), cocamidopropyl betaine (9.5%), methylchloroisothiazolinone/methylisothiazolinone (8.4%), coconut diethanolamide (7.9%), fragrance mix I (7.7%), Myroxylon pereirae (5.9%), 4-chloro-3,5-xylenol (5.8%), amidoamine (5.5%), and formaldehyde (4.4%). Conclusions Many allergens, especially preservatives and surfactants, were associated with SCs. Most cases involved the hands and were occupationally related.

Original languageEnglish (US)
Pages (from-to)32-42
Number of pages11
JournalDermatitis
Volume29
Issue number1
DOIs
StatePublished - Jan 1 2018

Fingerprint

Patch Tests
Contact Dermatitis
Irritants
Skin
Confidence Intervals
Irritant Dermatitis
Hand
Dermatitis
Allergens
Myroxylon
Skin Diseases
Surface-Active Agents
Formaldehyde
Arm
Cross-Sectional Studies

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Dermatology

Cite this

Warshaw, E. M., Goodier, M. C., Dekoven, J. G., Maibach, H. I., Taylor, J. S., Sasseville, D., ... Zug, K. A. (2018). Contact Dermatitis Associated with Skin Cleansers: Retrospective Analysis of North American Contact Dermatitis Group Data 2000-2014. Dermatitis, 29(1), 32-42. https://doi.org/10.1097/DER.0000000000000330
Warshaw, Erin M. ; Goodier, Molly C. ; Dekoven, Joel G. ; Maibach, Howard I. ; Taylor, James S. ; Sasseville, Denis ; Belsito, Donald V. ; Fowler, Joseph F. ; Fransway, Anthony F. ; Deleo, Vincent A. ; Marks, James ; Pratt, Melanie D. ; Mathias, Toby ; Zirwas, Matthew J. ; Zug, Kathryn A. / Contact Dermatitis Associated with Skin Cleansers : Retrospective Analysis of North American Contact Dermatitis Group Data 2000-2014. In: Dermatitis. 2018 ; Vol. 29, No. 1. pp. 32-42.
@article{fbdd55f762624c9cb4d3d93b1c6f7b27,
title = "Contact Dermatitis Associated with Skin Cleansers: Retrospective Analysis of North American Contact Dermatitis Group Data 2000-2014",
abstract = "Background There is limited information regarding contact dermatitis (CD) associated with skin cleansers (SCs). Objective The aim of the study was to evaluate the prevalence of allergic patch test (APT) reactions and irritant CD (ICD) associated with SCs. Methods A retrospective cross-sectional analysis was performed using North American Contact Dermatitis Group data, 2000-2014. Results Of 32,945 tested patients, 1069 (3.24{\%}) had either APT reaction or ICD associated with SCs. Of these, 692 (64.7{\%}) had APT reaction only, 350 (32.7{\%}) had ICD only, and 27 (2.5{\%}) had both. Individuals with APT reaction and/or ICD were more likely to have occupationally related skin disease (relative risk [RR] = 3.8 [95{\%} confidence interval {CI} = 3.3-4.5] for APT reaction and 10.0 [95{\%} CI = 8.2-12.2] for ICD, respectively, P < 0.0001). As compared with those without APT reaction to SC, individuals with APT reaction had significantly higher frequencies of hand (RR = 2.4 [95{\%} CI = 2.1-2.7]) and arm dermatitis (RR = 1.3 [95{\%} CI = 1.1-1.6], P ≤ 0.001). Irritant CD was strongly associated with hand dermatitis (RR = 6.2 [95{\%} CI = 5.2-7.3], P < 0.0001). More than 50 allergens were associated with SCs including quaternium-15 (11.2{\%}), cocamidopropyl betaine (9.5{\%}), methylchloroisothiazolinone/methylisothiazolinone (8.4{\%}), coconut diethanolamide (7.9{\%}), fragrance mix I (7.7{\%}), Myroxylon pereirae (5.9{\%}), 4-chloro-3,5-xylenol (5.8{\%}), amidoamine (5.5{\%}), and formaldehyde (4.4{\%}). Conclusions Many allergens, especially preservatives and surfactants, were associated with SCs. Most cases involved the hands and were occupationally related.",
author = "Warshaw, {Erin M.} and Goodier, {Molly C.} and Dekoven, {Joel G.} and Maibach, {Howard I.} and Taylor, {James S.} and Denis Sasseville and Belsito, {Donald V.} and Fowler, {Joseph F.} and Fransway, {Anthony F.} and Deleo, {Vincent A.} and James Marks and Pratt, {Melanie D.} and Toby Mathias and Zirwas, {Matthew J.} and Zug, {Kathryn A.}",
year = "2018",
month = "1",
day = "1",
doi = "10.1097/DER.0000000000000330",
language = "English (US)",
volume = "29",
pages = "32--42",
journal = "Dermatitis",
issn = "1710-3568",
publisher = "Decker Publishing",
number = "1",

}

Warshaw, EM, Goodier, MC, Dekoven, JG, Maibach, HI, Taylor, JS, Sasseville, D, Belsito, DV, Fowler, JF, Fransway, AF, Deleo, VA, Marks, J, Pratt, MD, Mathias, T, Zirwas, MJ & Zug, KA 2018, 'Contact Dermatitis Associated with Skin Cleansers: Retrospective Analysis of North American Contact Dermatitis Group Data 2000-2014', Dermatitis, vol. 29, no. 1, pp. 32-42. https://doi.org/10.1097/DER.0000000000000330

Contact Dermatitis Associated with Skin Cleansers : Retrospective Analysis of North American Contact Dermatitis Group Data 2000-2014. / Warshaw, Erin M.; Goodier, Molly C.; Dekoven, Joel G.; Maibach, Howard I.; Taylor, James S.; Sasseville, Denis; Belsito, Donald V.; Fowler, Joseph F.; Fransway, Anthony F.; Deleo, Vincent A.; Marks, James; Pratt, Melanie D.; Mathias, Toby; Zirwas, Matthew J.; Zug, Kathryn A.

In: Dermatitis, Vol. 29, No. 1, 01.01.2018, p. 32-42.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Contact Dermatitis Associated with Skin Cleansers

T2 - Retrospective Analysis of North American Contact Dermatitis Group Data 2000-2014

AU - Warshaw, Erin M.

AU - Goodier, Molly C.

AU - Dekoven, Joel G.

AU - Maibach, Howard I.

AU - Taylor, James S.

AU - Sasseville, Denis

AU - Belsito, Donald V.

AU - Fowler, Joseph F.

AU - Fransway, Anthony F.

AU - Deleo, Vincent A.

AU - Marks, James

AU - Pratt, Melanie D.

AU - Mathias, Toby

AU - Zirwas, Matthew J.

AU - Zug, Kathryn A.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background There is limited information regarding contact dermatitis (CD) associated with skin cleansers (SCs). Objective The aim of the study was to evaluate the prevalence of allergic patch test (APT) reactions and irritant CD (ICD) associated with SCs. Methods A retrospective cross-sectional analysis was performed using North American Contact Dermatitis Group data, 2000-2014. Results Of 32,945 tested patients, 1069 (3.24%) had either APT reaction or ICD associated with SCs. Of these, 692 (64.7%) had APT reaction only, 350 (32.7%) had ICD only, and 27 (2.5%) had both. Individuals with APT reaction and/or ICD were more likely to have occupationally related skin disease (relative risk [RR] = 3.8 [95% confidence interval {CI} = 3.3-4.5] for APT reaction and 10.0 [95% CI = 8.2-12.2] for ICD, respectively, P < 0.0001). As compared with those without APT reaction to SC, individuals with APT reaction had significantly higher frequencies of hand (RR = 2.4 [95% CI = 2.1-2.7]) and arm dermatitis (RR = 1.3 [95% CI = 1.1-1.6], P ≤ 0.001). Irritant CD was strongly associated with hand dermatitis (RR = 6.2 [95% CI = 5.2-7.3], P < 0.0001). More than 50 allergens were associated with SCs including quaternium-15 (11.2%), cocamidopropyl betaine (9.5%), methylchloroisothiazolinone/methylisothiazolinone (8.4%), coconut diethanolamide (7.9%), fragrance mix I (7.7%), Myroxylon pereirae (5.9%), 4-chloro-3,5-xylenol (5.8%), amidoamine (5.5%), and formaldehyde (4.4%). Conclusions Many allergens, especially preservatives and surfactants, were associated with SCs. Most cases involved the hands and were occupationally related.

AB - Background There is limited information regarding contact dermatitis (CD) associated with skin cleansers (SCs). Objective The aim of the study was to evaluate the prevalence of allergic patch test (APT) reactions and irritant CD (ICD) associated with SCs. Methods A retrospective cross-sectional analysis was performed using North American Contact Dermatitis Group data, 2000-2014. Results Of 32,945 tested patients, 1069 (3.24%) had either APT reaction or ICD associated with SCs. Of these, 692 (64.7%) had APT reaction only, 350 (32.7%) had ICD only, and 27 (2.5%) had both. Individuals with APT reaction and/or ICD were more likely to have occupationally related skin disease (relative risk [RR] = 3.8 [95% confidence interval {CI} = 3.3-4.5] for APT reaction and 10.0 [95% CI = 8.2-12.2] for ICD, respectively, P < 0.0001). As compared with those without APT reaction to SC, individuals with APT reaction had significantly higher frequencies of hand (RR = 2.4 [95% CI = 2.1-2.7]) and arm dermatitis (RR = 1.3 [95% CI = 1.1-1.6], P ≤ 0.001). Irritant CD was strongly associated with hand dermatitis (RR = 6.2 [95% CI = 5.2-7.3], P < 0.0001). More than 50 allergens were associated with SCs including quaternium-15 (11.2%), cocamidopropyl betaine (9.5%), methylchloroisothiazolinone/methylisothiazolinone (8.4%), coconut diethanolamide (7.9%), fragrance mix I (7.7%), Myroxylon pereirae (5.9%), 4-chloro-3,5-xylenol (5.8%), amidoamine (5.5%), and formaldehyde (4.4%). Conclusions Many allergens, especially preservatives and surfactants, were associated with SCs. Most cases involved the hands and were occupationally related.

UR - http://www.scopus.com/inward/record.url?scp=85040842137&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85040842137&partnerID=8YFLogxK

U2 - 10.1097/DER.0000000000000330

DO - 10.1097/DER.0000000000000330

M3 - Article

C2 - 29256904

AN - SCOPUS:85040842137

VL - 29

SP - 32

EP - 42

JO - Dermatitis

JF - Dermatitis

SN - 1710-3568

IS - 1

ER -