TY - JOUR
T1 - Continuous measurement of object location memory is sensitive to effects of age and mild cognitive impairment and related to medial temporal lobe volume
AU - Hampstead, Benjamin M.
AU - Towler, Stephen
AU - Stringer, Anthony Y.
AU - Sathian, Krishnankutty
N1 - Funding Information:
Those interested in using the OLTT for academic and additional validation purposes are encouraged to contact the corresponding author. This work was supported by the Department of Veterans Affairs (B6366 W and IRX001534 to BMH) and partially by the National Institute on Aging funded Emory Alzheimer's Disease Research Center (2P50AG025688) and Michigan Alzheimer's Disease Core Center (5P30AG053760). The contents of this manuscript do not represent the views of the Department of Veterans Affairs or the United States Government.
Publisher Copyright:
© 2017
PY - 2018
Y1 - 2018
N2 - Introduction We present findings of a novel and ecologically relevant associative memory test, the Object Location Touchscreen Test (OLTT), which was posited as sensitive to early medial temporal lobe compromise associated with mild cognitive impairment (MCI). Methods A total of 114 participants, including healthy young and older controls and patients with MCI, completed the OLTT and standard neuropsychological testing. The OLTT required participants to recall the location of objects under free and cued recall conditions, with accuracy evaluated using distance measures (i.e., a continuous error score), and a standard recognition format. Correlations between performance and volumetric data were evaluated from a subset of 77 participants. Results Significant age effects were dwarfed by MCI effects across all test conditions. OLTT Cued Recall was strongly and specifically related to the volume of disease-relevant medial temporal lobe regions, generally more than traditional memory tests. Discussion The OLTT may be sensitive to early structural compromise in regions affected by Alzheimer's disease.
AB - Introduction We present findings of a novel and ecologically relevant associative memory test, the Object Location Touchscreen Test (OLTT), which was posited as sensitive to early medial temporal lobe compromise associated with mild cognitive impairment (MCI). Methods A total of 114 participants, including healthy young and older controls and patients with MCI, completed the OLTT and standard neuropsychological testing. The OLTT required participants to recall the location of objects under free and cued recall conditions, with accuracy evaluated using distance measures (i.e., a continuous error score), and a standard recognition format. Correlations between performance and volumetric data were evaluated from a subset of 77 participants. Results Significant age effects were dwarfed by MCI effects across all test conditions. OLTT Cued Recall was strongly and specifically related to the volume of disease-relevant medial temporal lobe regions, generally more than traditional memory tests. Discussion The OLTT may be sensitive to early structural compromise in regions affected by Alzheimer's disease.
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U2 - 10.1016/j.dadm.2017.10.007
DO - 10.1016/j.dadm.2017.10.007
M3 - Article
C2 - 29255787
AN - SCOPUS:85035805212
SN - 2352-8729
VL - 10
SP - 76
EP - 85
JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
ER -