Continuous separations with microfabricated electrophoresis-electrochemical array detection

Peter F. Gavin, Andrew G. Ewing

Research output: Contribution to journalArticlepeer-review

85 Scopus citations

Abstract

A novel electrochemical detection scheme for channel electrophoresis has been developed. A microfabricated array of individually addressed microelectrodes has been used as a site-specific amperometric detector for continuous separations in a buffer-filled rectangular channel. Continuous separations of picomole quantities of dopamine and catechol by channel electrophoresis with this new detection scheme have been demonstrated. Dopamine, an electroactive neurotransmitter, has been continuously monitored for 60 min with the electrochemical array detector. The new detection technique should allow dynamic chemical events in volume-limited microenvironments (i.e. single cells) to be examined with channel electrophoresis.

Original languageEnglish (US)
Pages (from-to)8932-8936
Number of pages5
JournalJournal of the American Chemical Society
Volume118
Issue number37
DOIs
StatePublished - Sep 18 1996

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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