Contralateral cranial polyneuropathy due to perineural invasion by a cutaneous squamous cell carcinoma

Arun N.E. Sundaram, Zachary Simmons, Javad Towfighi, Jonas Sheehan, Raymond Reichwein

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Cutaneous malignancies may spread to underlying nerves, a process known as perineural invasion (PNI). We report a patient who was found to have PNI presenting as a cranial polyneuropathy on the contralateral side of the face many years after the resection of a squamous cell carcinoma. All diagnostic testing was unrevealing until nerve biopsy was performed. This emphasizes the long asymptomatic period between treatment of a cutaneous malignancy and detection of PNI, and the development of PNI at a site distant from the original malignancy. Biopsy of a clinically involved nerve may permit diagnosis of PNI when other studies are normal.

Original languageEnglish (US)
Pages (from-to)132-136
Number of pages5
JournalJournal of clinical neuromuscular disease
Volume11
Issue number3
DOIs
StatePublished - Mar 2010

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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