Contrasting Responses of Lizards to Divergent Ecological Stressors Across Biological Levels of Organization

Rory S. Telemeco, Dasia Y. Simpson, Catherine Tylan, Tracy Lee Langkilde, Tonia S. Schwartz

Research output: Contribution to journalArticle

Abstract

It is frequently hypothesized that animals employ a generalized "stress response," largely mediated by glucocorticoid (GC) hormones, such as corticosterone, to combat challenging environmental conditions. Under this hypothesis, diverse stressors are predicted to have concordant effects across biological levels of an organism. We tested the generalized stress response hypothesis in two complementary experiments with juvenile and adult male Eastern fence lizards (Sceloporus undulatus). In both experiments, animals were exposed to diverse, ecologically-relevant, acute stressors (high temperature or red imported fire ants, Solenopsis invicta) and we examined their responses at three biological levels: behavioral; physiological (endocrine [plasma corticosterone and blood glucose concentrations] and innate immunity [complement and natural antibodies]); and cellular responses (gene expression of a panel of five heat-shock proteins in blood and liver) at 30 or 90 min post stress initiation. In both experiments, we observed large differences in the cellular response to the two stressors, which contrasts the similar behavioral and endocrine responses. In the adult experiment for which we had innate immune data, the stressors affected immune function independently, and they were correlated with CORT in opposing directions. Taken together, these results challenge the concept of a generalized stress response. Rather, the stress response was context specific, especially at the cellular level. Such context-specificity might explain why attempts to link GC hormones with life history and fitness have proved difficult. Our results emphasize the need for indicators at multiple biological levels and whole-organism examinations of stress.

Original languageEnglish (US)
Pages (from-to)292-305
Number of pages14
JournalIntegrative and comparative biology
Volume59
Issue number2
DOIs
StatePublished - Aug 1 2019

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lizards
stress response
Sceloporus undulatus
Solenopsis invicta
corticosterone
glucocorticoids
hormones
organisms
heat shock proteins
blood glucose
laboratory animals
complement
life history
gene expression
liver
environmental factors
antibodies
blood
animals
temperature

All Science Journal Classification (ASJC) codes

  • Animal Science and Zoology
  • Plant Science

Cite this

Telemeco, Rory S. ; Simpson, Dasia Y. ; Tylan, Catherine ; Langkilde, Tracy Lee ; Schwartz, Tonia S. / Contrasting Responses of Lizards to Divergent Ecological Stressors Across Biological Levels of Organization. In: Integrative and comparative biology. 2019 ; Vol. 59, No. 2. pp. 292-305.
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Contrasting Responses of Lizards to Divergent Ecological Stressors Across Biological Levels of Organization. / Telemeco, Rory S.; Simpson, Dasia Y.; Tylan, Catherine; Langkilde, Tracy Lee; Schwartz, Tonia S.

In: Integrative and comparative biology, Vol. 59, No. 2, 01.08.2019, p. 292-305.

Research output: Contribution to journalArticle

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