Control of CNS Functions by RNA-Binding Proteins in Neurological Diseases

Yijing Zhou, Fengping Dong, Yingwei Mao

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Purpose of Review: This review summarizes recent studies on the molecular mechanisms of RNA-binding proteins (RBPs) that control neurological functions and pathogenesis in various neurodevelopmental and neurodegenerative diseases, including autism spectrum disorders, schizophrenia, Alzheimer’s disease, amyotrophic lateral sclerosis, frontotemporal dementia, and spinocerebellar ataxia. Recent Findings: RBPs are critical players that regulate every step of posttranscriptional modifications of gene expression. Recent genome-wide approaches revealed that many proteins associate with RNA, but do not contain any known RNA-binding motifs. Additionally, many causal and risk genes of neurodevelopmental and neurodegenerative diseases are RBPs. Development of high-throughput sequencing methods has mapped out the fingerprints of RBPs on transcripts and provided unprecedented potential to discover new mechanisms of neurological diseases. Insights into how RBPs modulate neural development are important for designing effective therapies for numerous neurodevelopmental and neurodegenerative diseases. Summary: RBPs have diverse mechanisms for modulating RNA processing and, thereby, controlling neurogenesis. Understanding the role of disease-associated RBPs in neurogenesis is vital for developing novel treatments for neurological diseases.

Original languageEnglish (US)
Pages (from-to)301-313
Number of pages13
JournalCurrent Pharmacology Reports
Volume4
Issue number4
DOIs
StatePublished - Aug 1 2018

Fingerprint

RNA-Binding Proteins
Neurodegenerative diseases
Neurodegenerative Diseases
Neurogenesis
RNA
Genes
Spinocerebellar Ataxias
Dermatoglyphics
Schizophrenia
Alzheimer Disease
Throughput
Genome
Processing

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Genetics
  • Pharmacology
  • Drug Discovery

Cite this

@article{bab8afe4a4664921a4670911c98de7e0,
title = "Control of CNS Functions by RNA-Binding Proteins in Neurological Diseases",
abstract = "Purpose of Review: This review summarizes recent studies on the molecular mechanisms of RNA-binding proteins (RBPs) that control neurological functions and pathogenesis in various neurodevelopmental and neurodegenerative diseases, including autism spectrum disorders, schizophrenia, Alzheimer’s disease, amyotrophic lateral sclerosis, frontotemporal dementia, and spinocerebellar ataxia. Recent Findings: RBPs are critical players that regulate every step of posttranscriptional modifications of gene expression. Recent genome-wide approaches revealed that many proteins associate with RNA, but do not contain any known RNA-binding motifs. Additionally, many causal and risk genes of neurodevelopmental and neurodegenerative diseases are RBPs. Development of high-throughput sequencing methods has mapped out the fingerprints of RBPs on transcripts and provided unprecedented potential to discover new mechanisms of neurological diseases. Insights into how RBPs modulate neural development are important for designing effective therapies for numerous neurodevelopmental and neurodegenerative diseases. Summary: RBPs have diverse mechanisms for modulating RNA processing and, thereby, controlling neurogenesis. Understanding the role of disease-associated RBPs in neurogenesis is vital for developing novel treatments for neurological diseases.",
author = "Yijing Zhou and Fengping Dong and Yingwei Mao",
year = "2018",
month = "8",
day = "1",
doi = "10.1007/s40495-018-0140-7",
language = "English (US)",
volume = "4",
pages = "301--313",
journal = "Current Pharmacology Reports",
issn = "2198-641X",
publisher = "Springer International Publishing AG",
number = "4",

}

Control of CNS Functions by RNA-Binding Proteins in Neurological Diseases. / Zhou, Yijing; Dong, Fengping; Mao, Yingwei.

In: Current Pharmacology Reports, Vol. 4, No. 4, 01.08.2018, p. 301-313.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Control of CNS Functions by RNA-Binding Proteins in Neurological Diseases

AU - Zhou, Yijing

AU - Dong, Fengping

AU - Mao, Yingwei

PY - 2018/8/1

Y1 - 2018/8/1

N2 - Purpose of Review: This review summarizes recent studies on the molecular mechanisms of RNA-binding proteins (RBPs) that control neurological functions and pathogenesis in various neurodevelopmental and neurodegenerative diseases, including autism spectrum disorders, schizophrenia, Alzheimer’s disease, amyotrophic lateral sclerosis, frontotemporal dementia, and spinocerebellar ataxia. Recent Findings: RBPs are critical players that regulate every step of posttranscriptional modifications of gene expression. Recent genome-wide approaches revealed that many proteins associate with RNA, but do not contain any known RNA-binding motifs. Additionally, many causal and risk genes of neurodevelopmental and neurodegenerative diseases are RBPs. Development of high-throughput sequencing methods has mapped out the fingerprints of RBPs on transcripts and provided unprecedented potential to discover new mechanisms of neurological diseases. Insights into how RBPs modulate neural development are important for designing effective therapies for numerous neurodevelopmental and neurodegenerative diseases. Summary: RBPs have diverse mechanisms for modulating RNA processing and, thereby, controlling neurogenesis. Understanding the role of disease-associated RBPs in neurogenesis is vital for developing novel treatments for neurological diseases.

AB - Purpose of Review: This review summarizes recent studies on the molecular mechanisms of RNA-binding proteins (RBPs) that control neurological functions and pathogenesis in various neurodevelopmental and neurodegenerative diseases, including autism spectrum disorders, schizophrenia, Alzheimer’s disease, amyotrophic lateral sclerosis, frontotemporal dementia, and spinocerebellar ataxia. Recent Findings: RBPs are critical players that regulate every step of posttranscriptional modifications of gene expression. Recent genome-wide approaches revealed that many proteins associate with RNA, but do not contain any known RNA-binding motifs. Additionally, many causal and risk genes of neurodevelopmental and neurodegenerative diseases are RBPs. Development of high-throughput sequencing methods has mapped out the fingerprints of RBPs on transcripts and provided unprecedented potential to discover new mechanisms of neurological diseases. Insights into how RBPs modulate neural development are important for designing effective therapies for numerous neurodevelopmental and neurodegenerative diseases. Summary: RBPs have diverse mechanisms for modulating RNA processing and, thereby, controlling neurogenesis. Understanding the role of disease-associated RBPs in neurogenesis is vital for developing novel treatments for neurological diseases.

UR - http://www.scopus.com/inward/record.url?scp=85046163374&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85046163374&partnerID=8YFLogxK

U2 - 10.1007/s40495-018-0140-7

DO - 10.1007/s40495-018-0140-7

M3 - Review article

C2 - 30410853

AN - SCOPUS:85046163374

VL - 4

SP - 301

EP - 313

JO - Current Pharmacology Reports

JF - Current Pharmacology Reports

SN - 2198-641X

IS - 4

ER -