2 Citations (Scopus)

Abstract

Spreading depression or depolarization is a large-scale pathological brain phenomenon related to migraine, stroke, hemorrhage and traumatic brain injury. Once initiated, spreading depression propagates across gray matter extruding potassium and other active molecules, collapsing the resting membrane electro-chemical gradient of cells leading to spike inactivation and cellular swelling, and propagates independently of synaptic transmission. We demonstrate the modulation, suppression and prevention of spreading depression utilizing applied transcortical DC electric fields in brain slices, measured with intrinsic optical imaging and potassium dye epifluorescence. We experimentally observe a surface-positive electric field induced forcing of spreading depression propagation to locations in cortex deeper than the unmodulated propagation path, whereby further propagation is confined and arrested even after field termination. The opposite surface-negative electric field polarity produces an increase in propagation velocity and a confinement of the wave to more superficial layers of cortex than the unmodulated propagation path. These field polarities are of opposite sign to the polarity that blocks neuronal spiking and seizures, and are consistent with biophysical models of spreading depression. The results demonstrate the potential feasibility of electrical control and prevention of spreading depression.

Original languageEnglish (US)
Article number8769
JournalScientific reports
Volume8
Issue number1
DOIs
StatePublished - Dec 1 2018

Fingerprint

Potassium
Optical Imaging
Brain
Migraine Disorders
Synaptic Transmission
Seizures
Coloring Agents
Stroke
Hemorrhage
Membranes
Gray Matter
Traumatic Brain Injury

All Science Journal Classification (ASJC) codes

  • General

Cite this

Whalen, Andrew J. ; Xiao, Ying ; Kadji, Herve ; Dahlem, Markus A. ; Gluckman, Bruce J. ; Schiff, Steven J. / Control of Spreading Depression with Electrical Fields. In: Scientific reports. 2018 ; Vol. 8, No. 1.
@article{dd3705dc12504d638ee11977e8a4a0da,
title = "Control of Spreading Depression with Electrical Fields",
abstract = "Spreading depression or depolarization is a large-scale pathological brain phenomenon related to migraine, stroke, hemorrhage and traumatic brain injury. Once initiated, spreading depression propagates across gray matter extruding potassium and other active molecules, collapsing the resting membrane electro-chemical gradient of cells leading to spike inactivation and cellular swelling, and propagates independently of synaptic transmission. We demonstrate the modulation, suppression and prevention of spreading depression utilizing applied transcortical DC electric fields in brain slices, measured with intrinsic optical imaging and potassium dye epifluorescence. We experimentally observe a surface-positive electric field induced forcing of spreading depression propagation to locations in cortex deeper than the unmodulated propagation path, whereby further propagation is confined and arrested even after field termination. The opposite surface-negative electric field polarity produces an increase in propagation velocity and a confinement of the wave to more superficial layers of cortex than the unmodulated propagation path. These field polarities are of opposite sign to the polarity that blocks neuronal spiking and seizures, and are consistent with biophysical models of spreading depression. The results demonstrate the potential feasibility of electrical control and prevention of spreading depression.",
author = "Whalen, {Andrew J.} and Ying Xiao and Herve Kadji and Dahlem, {Markus A.} and Gluckman, {Bruce J.} and Schiff, {Steven J.}",
year = "2018",
month = "12",
day = "1",
doi = "10.1038/s41598-018-26986-1",
language = "English (US)",
volume = "8",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

Control of Spreading Depression with Electrical Fields. / Whalen, Andrew J.; Xiao, Ying; Kadji, Herve; Dahlem, Markus A.; Gluckman, Bruce J.; Schiff, Steven J.

In: Scientific reports, Vol. 8, No. 1, 8769, 01.12.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Control of Spreading Depression with Electrical Fields

AU - Whalen, Andrew J.

AU - Xiao, Ying

AU - Kadji, Herve

AU - Dahlem, Markus A.

AU - Gluckman, Bruce J.

AU - Schiff, Steven J.

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Spreading depression or depolarization is a large-scale pathological brain phenomenon related to migraine, stroke, hemorrhage and traumatic brain injury. Once initiated, spreading depression propagates across gray matter extruding potassium and other active molecules, collapsing the resting membrane electro-chemical gradient of cells leading to spike inactivation and cellular swelling, and propagates independently of synaptic transmission. We demonstrate the modulation, suppression and prevention of spreading depression utilizing applied transcortical DC electric fields in brain slices, measured with intrinsic optical imaging and potassium dye epifluorescence. We experimentally observe a surface-positive electric field induced forcing of spreading depression propagation to locations in cortex deeper than the unmodulated propagation path, whereby further propagation is confined and arrested even after field termination. The opposite surface-negative electric field polarity produces an increase in propagation velocity and a confinement of the wave to more superficial layers of cortex than the unmodulated propagation path. These field polarities are of opposite sign to the polarity that blocks neuronal spiking and seizures, and are consistent with biophysical models of spreading depression. The results demonstrate the potential feasibility of electrical control and prevention of spreading depression.

AB - Spreading depression or depolarization is a large-scale pathological brain phenomenon related to migraine, stroke, hemorrhage and traumatic brain injury. Once initiated, spreading depression propagates across gray matter extruding potassium and other active molecules, collapsing the resting membrane electro-chemical gradient of cells leading to spike inactivation and cellular swelling, and propagates independently of synaptic transmission. We demonstrate the modulation, suppression and prevention of spreading depression utilizing applied transcortical DC electric fields in brain slices, measured with intrinsic optical imaging and potassium dye epifluorescence. We experimentally observe a surface-positive electric field induced forcing of spreading depression propagation to locations in cortex deeper than the unmodulated propagation path, whereby further propagation is confined and arrested even after field termination. The opposite surface-negative electric field polarity produces an increase in propagation velocity and a confinement of the wave to more superficial layers of cortex than the unmodulated propagation path. These field polarities are of opposite sign to the polarity that blocks neuronal spiking and seizures, and are consistent with biophysical models of spreading depression. The results demonstrate the potential feasibility of electrical control and prevention of spreading depression.

UR - http://www.scopus.com/inward/record.url?scp=85048311369&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85048311369&partnerID=8YFLogxK

U2 - 10.1038/s41598-018-26986-1

DO - 10.1038/s41598-018-26986-1

M3 - Article

C2 - 29884896

AN - SCOPUS:85048311369

VL - 8

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 8769

ER -