Control of the arteriolar myogenic response by transvascular fluid filtration

Min Ho Kim, Norman R. Harris, Donna Hope Korzick, John M. Tarbell

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Mechanisms of the myogenic response have not been completely established. We hypothesized that transvascular fluid filtration from plasma across smooth muscle cells (SMC) and into the surrounding interstitium helps regulate arteriolar myogenic tone. Arteriolar diameters in the rat mesentery were monitored before and following vascular occlusion with a glass micropipette. Arteriolar occlusion not only gave an increase in hydrostatic pressure that initiated myogenic constriction upstream of the pipette, but also allowed measurement of fluid filtration rate by monitoring the movement of vascular red blood cells. A statistically significant correlation (P < 0.001) existed between basal myogenic tone and fluid filtration. Additionally, the myogenic response was attenuated by 47% ± 7% (N = 10) when an osmotic solution of albumin or albumin plus Ficoll was infused into the bloodstream to decrease fluid filtration by 53% ± 3%. Moreover, the same inhibition of myogenic tone was found in isolated, cannulated rat soleus muscle arterioles when filtration was osmotically attenuated by intravascular dextran. Taken together, these results are consistent with the hypothesis that shear stress on arteriolar smooth muscle, induced by transvascular fluid filtration, is a contributing factor that helps control myogenic tone.

Original languageEnglish (US)
Pages (from-to)30-37
Number of pages8
JournalMicrovascular Research
Volume68
Issue number1
DOIs
StatePublished - Jul 1 2004

Fingerprint

Fluids
Muscle
Blood Vessels
Rats
Albumins
Cells
Ficoll
Hydrostatic Pressure
Mesentery
Arterioles
Hydrostatic pressure
Dextrans
Constriction
Smooth Muscle Myocytes
Glass
Smooth Muscle
Shear stress
Skeletal Muscle
Blood
Erythrocytes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cardiology and Cardiovascular Medicine
  • Cell Biology

Cite this

Kim, Min Ho ; Harris, Norman R. ; Korzick, Donna Hope ; Tarbell, John M. / Control of the arteriolar myogenic response by transvascular fluid filtration. In: Microvascular Research. 2004 ; Vol. 68, No. 1. pp. 30-37.
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Control of the arteriolar myogenic response by transvascular fluid filtration. / Kim, Min Ho; Harris, Norman R.; Korzick, Donna Hope; Tarbell, John M.

In: Microvascular Research, Vol. 68, No. 1, 01.07.2004, p. 30-37.

Research output: Contribution to journalArticle

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