TY - JOUR
T1 - Control of traveling waves in the mammalian cortex
AU - Richardson, Kristen A.
AU - Schiff, Steven J.
AU - Gluckman, Bruce J.
PY - 2005/1/21
Y1 - 2005/1/21
N2 - We experimentally confirmed predictions that modulation of the neuronal threshold with electrical fields can speed up, slow down, and even block traveling waves in neocortical slices. The predictions are based on a Wilson-Cowan-type integro-differential equation model of propagating neocortical activity. Wave propagation could be modified quickly and reversibly within targeted regions of the network. To the best of our knowledge, this is the first example of direct modulation of the threshold to control wave propagation in a neural system.
AB - We experimentally confirmed predictions that modulation of the neuronal threshold with electrical fields can speed up, slow down, and even block traveling waves in neocortical slices. The predictions are based on a Wilson-Cowan-type integro-differential equation model of propagating neocortical activity. Wave propagation could be modified quickly and reversibly within targeted regions of the network. To the best of our knowledge, this is the first example of direct modulation of the threshold to control wave propagation in a neural system.
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U2 - 10.1103/PhysRevLett.94.028103
DO - 10.1103/PhysRevLett.94.028103
M3 - Article
C2 - 15698234
AN - SCOPUS:18144371247
VL - 94
JO - Physical Review Letters
JF - Physical Review Letters
SN - 0031-9007
IS - 2
M1 - 028103
ER -