Abstract

We experimentally confirmed predictions that modulation of the neuronal threshold with electrical fields can speed up, slow down, and even block traveling waves in neocortical slices. The predictions are based on a Wilson-Cowan-type integro-differential equation model of propagating neocortical activity. Wave propagation could be modified quickly and reversibly within targeted regions of the network. To the best of our knowledge, this is the first example of direct modulation of the threshold to control wave propagation in a neural system.

Original languageEnglish (US)
Article number028103
JournalPhysical review letters
Volume94
Issue number2
DOIs
StatePublished - Jan 21 2005

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)

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