Controlled and Sequential Delivery of Fluorophores from 3D Printed Alginate-PLGA Tubes

Anh Vu Do, Adil Akkouch, Brian Green, Ibrahim Ozbolat, Amer Debabneh, Sean Geary, Aliasger K. Salem

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Controlled drug delivery systems, that include sequential and/or sustained drug delivery, have been utilized to enhance the therapeutic effects of many current drugs by effectively delivering drugs in a time-dependent and repeatable manner. In this study, with the aid of 3D printing technology, a novel drug delivery device was fabricated and tested to evaluate sequential delivery functionality. With an alginate shell and a poly(lactic-co-glycolic acid) (PLGA) core, the fabricated tubes displayed sequential release of distinct fluorescent dyes and showed no cytotoxicity when incubated with the human embryonic kidney (HEK293) cell line or bone marrow stromal stem cells (BMSC). The controlled differential release of drugs or proteins through such a delivery system has the potential to be used in a wide variety of biomedical applications from treating cancer to regenerative medicine.

Original languageEnglish (US)
Pages (from-to)297-305
Number of pages9
JournalAnnals of Biomedical Engineering
Volume45
Issue number1
DOIs
StatePublished - Jan 1 2017

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All Science Journal Classification (ASJC) codes

  • Biomedical Engineering

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