Controlled release of macromolecules from poly(phosphazene) matrices

S. M. Ibim, A. Ambrosio, D. Larrier, Harry R. Allcock, C. T. Laurencin

Research output: Contribution to conferencePaper

Abstract

The suitability of amino acid matrices containing poly(phosphazenes) for the controlled release of large molecules is investigated. Mass loss or degradation studies and drug release studies were performed. The polymer matrix degraded fastest in strongly acidic media (pH 2.0) and at a slower rate in neutral (pH 7.4) and basic media (pH 10.0). Polymer degradation was found to increase with drug loading in the matrix. Drug release from the matrix was characterized by a burst effect followed by nearly constant kinetics. Increased drug loading resulted in increased hydrophilicity which promoted degradation and diffusion. The phosphazene matrices studied reproducibly released insulin in a controlled manner.

Original languageEnglish (US)
Number of pages1
StatePublished - Dec 1 1996
EventProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can
Duration: May 29 1996Jun 2 1996

Other

OtherProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
CityToronto, Can
Period5/29/966/2/96

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Macromolecules
Degradation
Pharmaceutical Preparations
Insulin
Hydrophilicity
Polymer matrix
Amino acids
Polymers
Molecules
Kinetics
Amino Acids
poly(phosphazene)

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

Cite this

Ibim, S. M., Ambrosio, A., Larrier, D., Allcock, H. R., & Laurencin, C. T. (1996). Controlled release of macromolecules from poly(phosphazene) matrices. Paper presented at Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2), Toronto, Can, .
Ibim, S. M. ; Ambrosio, A. ; Larrier, D. ; Allcock, Harry R. ; Laurencin, C. T. / Controlled release of macromolecules from poly(phosphazene) matrices. Paper presented at Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2), Toronto, Can, .1 p.
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Ibim, SM, Ambrosio, A, Larrier, D, Allcock, HR & Laurencin, CT 1996, 'Controlled release of macromolecules from poly(phosphazene) matrices', Paper presented at Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2), Toronto, Can, 5/29/96 - 6/2/96.

Controlled release of macromolecules from poly(phosphazene) matrices. / Ibim, S. M.; Ambrosio, A.; Larrier, D.; Allcock, Harry R.; Laurencin, C. T.

1996. Paper presented at Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2), Toronto, Can, .

Research output: Contribution to conferencePaper

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T1 - Controlled release of macromolecules from poly(phosphazene) matrices

AU - Ibim, S. M.

AU - Ambrosio, A.

AU - Larrier, D.

AU - Allcock, Harry R.

AU - Laurencin, C. T.

PY - 1996/12/1

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N2 - The suitability of amino acid matrices containing poly(phosphazenes) for the controlled release of large molecules is investigated. Mass loss or degradation studies and drug release studies were performed. The polymer matrix degraded fastest in strongly acidic media (pH 2.0) and at a slower rate in neutral (pH 7.4) and basic media (pH 10.0). Polymer degradation was found to increase with drug loading in the matrix. Drug release from the matrix was characterized by a burst effect followed by nearly constant kinetics. Increased drug loading resulted in increased hydrophilicity which promoted degradation and diffusion. The phosphazene matrices studied reproducibly released insulin in a controlled manner.

AB - The suitability of amino acid matrices containing poly(phosphazenes) for the controlled release of large molecules is investigated. Mass loss or degradation studies and drug release studies were performed. The polymer matrix degraded fastest in strongly acidic media (pH 2.0) and at a slower rate in neutral (pH 7.4) and basic media (pH 10.0). Polymer degradation was found to increase with drug loading in the matrix. Drug release from the matrix was characterized by a burst effect followed by nearly constant kinetics. Increased drug loading resulted in increased hydrophilicity which promoted degradation and diffusion. The phosphazene matrices studied reproducibly released insulin in a controlled manner.

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Ibim SM, Ambrosio A, Larrier D, Allcock HR, Laurencin CT. Controlled release of macromolecules from poly(phosphazene) matrices. 1996. Paper presented at Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2), Toronto, Can, .