Coping style as a protective factor for emotional consequences of structural neuropathology in multiple sclerosis

Dede M. Ukueberuwa, Peter Andrew Arnett

Research output: Contribution to journalArticle

Abstract

Introduction: In people with multiple sclerosis (MS), depression symptoms could be a direct consequence of neuropathological processes or a secondary consequence of coping with debilitating illness. We investigated the interaction of white matter structure and patient coping style in predicting positive and negative emotion symptoms of depression. Method: Participants completed a neuropsychological battery, including the Chicago Multiscale Depression Inventory (CMDI) and a measure of coping strategies that has Active Coping (more adaptive) and Avoidant Coping (less adaptive) scales. Participants also completed a diffusion tensor imaging (DTI) scan, from which fractional anisotropy (FA) was calculated to assess integrity in tracts of interest, and the interaction of FA and coping style was analyzed to predict depression symptoms. Results: Significant FA and Active Coping interaction effects for predicting CMDI Negative Emotion scores were found for the anterior thalamic radiation and uncinate fasciculus white matter tracts. For people with MS who showed relatively reduced integrity of these tracts, use of more Active Coping moderated the relationship of microstructure and negative emotion symptoms of depression. This moderating relationship was not seen with other tracts of interest or with positive emotion. Conclusion: There was a protective effect of adaptive coping style against the experience of negative emotion among people with MS who showed compromised regional white matter integrity of certain tracts that connect temporal and thalamic regions to frontal cortex.

Original languageEnglish (US)
Pages (from-to)390-398
Number of pages9
JournalJournal of Clinical and Experimental Neuropsychology
Volume41
Issue number4
DOIs
StatePublished - Apr 21 2019

Fingerprint

Multiple Sclerosis
Depression
Emotions
Anisotropy
Equipment and Supplies
Diffusion Tensor Imaging
Frontal Lobe
Temporal Lobe
Neuropathology
Protective Factors
Radiation
White Matter

All Science Journal Classification (ASJC) codes

  • Clinical Psychology
  • Neurology
  • Clinical Neurology

Cite this

@article{8820dcd38c0041cb814ecd735e5b123b,
title = "Coping style as a protective factor for emotional consequences of structural neuropathology in multiple sclerosis",
abstract = "Introduction: In people with multiple sclerosis (MS), depression symptoms could be a direct consequence of neuropathological processes or a secondary consequence of coping with debilitating illness. We investigated the interaction of white matter structure and patient coping style in predicting positive and negative emotion symptoms of depression. Method: Participants completed a neuropsychological battery, including the Chicago Multiscale Depression Inventory (CMDI) and a measure of coping strategies that has Active Coping (more adaptive) and Avoidant Coping (less adaptive) scales. Participants also completed a diffusion tensor imaging (DTI) scan, from which fractional anisotropy (FA) was calculated to assess integrity in tracts of interest, and the interaction of FA and coping style was analyzed to predict depression symptoms. Results: Significant FA and Active Coping interaction effects for predicting CMDI Negative Emotion scores were found for the anterior thalamic radiation and uncinate fasciculus white matter tracts. For people with MS who showed relatively reduced integrity of these tracts, use of more Active Coping moderated the relationship of microstructure and negative emotion symptoms of depression. This moderating relationship was not seen with other tracts of interest or with positive emotion. Conclusion: There was a protective effect of adaptive coping style against the experience of negative emotion among people with MS who showed compromised regional white matter integrity of certain tracts that connect temporal and thalamic regions to frontal cortex.",
author = "Ukueberuwa, {Dede M.} and Arnett, {Peter Andrew}",
year = "2019",
month = "4",
day = "21",
doi = "10.1080/13803395.2019.1566443",
language = "English (US)",
volume = "41",
pages = "390--398",
journal = "Journal of Clinical and Experimental Neuropsychology",
issn = "0168-8634",
publisher = "Psychology Press Ltd",
number = "4",

}

TY - JOUR

T1 - Coping style as a protective factor for emotional consequences of structural neuropathology in multiple sclerosis

AU - Ukueberuwa, Dede M.

AU - Arnett, Peter Andrew

PY - 2019/4/21

Y1 - 2019/4/21

N2 - Introduction: In people with multiple sclerosis (MS), depression symptoms could be a direct consequence of neuropathological processes or a secondary consequence of coping with debilitating illness. We investigated the interaction of white matter structure and patient coping style in predicting positive and negative emotion symptoms of depression. Method: Participants completed a neuropsychological battery, including the Chicago Multiscale Depression Inventory (CMDI) and a measure of coping strategies that has Active Coping (more adaptive) and Avoidant Coping (less adaptive) scales. Participants also completed a diffusion tensor imaging (DTI) scan, from which fractional anisotropy (FA) was calculated to assess integrity in tracts of interest, and the interaction of FA and coping style was analyzed to predict depression symptoms. Results: Significant FA and Active Coping interaction effects for predicting CMDI Negative Emotion scores were found for the anterior thalamic radiation and uncinate fasciculus white matter tracts. For people with MS who showed relatively reduced integrity of these tracts, use of more Active Coping moderated the relationship of microstructure and negative emotion symptoms of depression. This moderating relationship was not seen with other tracts of interest or with positive emotion. Conclusion: There was a protective effect of adaptive coping style against the experience of negative emotion among people with MS who showed compromised regional white matter integrity of certain tracts that connect temporal and thalamic regions to frontal cortex.

AB - Introduction: In people with multiple sclerosis (MS), depression symptoms could be a direct consequence of neuropathological processes or a secondary consequence of coping with debilitating illness. We investigated the interaction of white matter structure and patient coping style in predicting positive and negative emotion symptoms of depression. Method: Participants completed a neuropsychological battery, including the Chicago Multiscale Depression Inventory (CMDI) and a measure of coping strategies that has Active Coping (more adaptive) and Avoidant Coping (less adaptive) scales. Participants also completed a diffusion tensor imaging (DTI) scan, from which fractional anisotropy (FA) was calculated to assess integrity in tracts of interest, and the interaction of FA and coping style was analyzed to predict depression symptoms. Results: Significant FA and Active Coping interaction effects for predicting CMDI Negative Emotion scores were found for the anterior thalamic radiation and uncinate fasciculus white matter tracts. For people with MS who showed relatively reduced integrity of these tracts, use of more Active Coping moderated the relationship of microstructure and negative emotion symptoms of depression. This moderating relationship was not seen with other tracts of interest or with positive emotion. Conclusion: There was a protective effect of adaptive coping style against the experience of negative emotion among people with MS who showed compromised regional white matter integrity of certain tracts that connect temporal and thalamic regions to frontal cortex.

UR - http://www.scopus.com/inward/record.url?scp=85060634429&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85060634429&partnerID=8YFLogxK

U2 - 10.1080/13803395.2019.1566443

DO - 10.1080/13803395.2019.1566443

M3 - Article

C2 - 30676253

AN - SCOPUS:85060634429

VL - 41

SP - 390

EP - 398

JO - Journal of Clinical and Experimental Neuropsychology

JF - Journal of Clinical and Experimental Neuropsychology

SN - 0168-8634

IS - 4

ER -