Copper-catalyzed carboxamide-directed ortho amination of anilines with alkylamines at room temperature

Qiong Li, Shu Yu Zhang, Gang He, Zhaoyan Ai, William A. Nack, Gong Chen

Research output: Contribution to journalArticle

134 Scopus citations

Abstract

In this report, a highly efficient method for the room temperature installation of alkyl amino motifs onto the ortho position of anilines via Cu-catalyzed carboxamide-directed amination with alkylamines is described. This method offers a practical solution for the rapid synthesis of complex arylamines from simple starting materials and enables new planning strategies for the construction of arylamine-containing pharmacophores. A single electron transfer (SET)-mediated mechanism is proposed.

Original languageEnglish (US)
Pages (from-to)1764-1767
Number of pages4
JournalOrganic Letters
Volume16
Issue number6
DOIs
StatePublished - Mar 21 2014

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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