Copper-Catalyzed Dicarbofunctionalization of Unactivated Olefins by Tandem Cyclization/Cross-Coupling

Surendra Thapa, Prakash Basnet, Ramesh Giri

Research output: Contribution to journalArticle

58 Scopus citations

Abstract

We present a strategy that difunctionalizes unactivated olefins in 1,2-positions with two carbon-based entities. This method utilizes alkyl/arylzinc reagents derived from olefin-tethered alkyl/aryl halides that undergo radical cyclization to generate C(sp3)-Cu complexes in situ, which are intercepted with aryl and heteroaryl iodides. A variety of (arylmethyl)carbo- and heterocycles (N, O) can be synthesized with this new method.

Original languageEnglish (US)
Pages (from-to)5700-5703
Number of pages4
JournalJournal of the American Chemical Society
Volume139
Issue number16
DOIs
StatePublished - Apr 26 2017

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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