Correction of a Glutathione Deficiency in the Aging Mosquito Increases Its Longevity

John Richie, Betty Jane Mills, Calvin A. Lang

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

The decrease of tissue glutathione (GSH) concentrations in different senescent organisms gave rise to our hypothesis that a glutathione deficiency is a biochemical cause of the aging process. A rigorous test of this notion would be the correction of the deficiency and concomitant increase in life span. To this end, adult mosquitoes were fed magnesium thiazolidine-4-carboxylic acid, and their GSH levels and life spans were determined. The GSH levels increased 50–100% (P < 0.005) regardless of the age when feeding was initiated or whether the feeding period extended over 2 days or the entire life span. Also the median life spans increased 30–38% over control values (P < 0.005). The responses were specific for the thiazolidine carboxylate moiety, because MgCl2 had no effect. These findings confirm the GSH deficiency hypothesis and demonstrate a specific biochemical mechanism of aging that can be nutritionally modified.

Original languageEnglish (US)
Pages (from-to)113-117
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume184
Issue number1
DOIs
StatePublished - Jan 1 1987

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Culicidae
Glutathione
Aging of materials
Thiazolidines
Magnesium Chloride
Magnesium
Tissue
thiazolidine-4-carboxylic acid

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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abstract = "The decrease of tissue glutathione (GSH) concentrations in different senescent organisms gave rise to our hypothesis that a glutathione deficiency is a biochemical cause of the aging process. A rigorous test of this notion would be the correction of the deficiency and concomitant increase in life span. To this end, adult mosquitoes were fed magnesium thiazolidine-4-carboxylic acid, and their GSH levels and life spans were determined. The GSH levels increased 50–100{\%} (P < 0.005) regardless of the age when feeding was initiated or whether the feeding period extended over 2 days or the entire life span. Also the median life spans increased 30–38{\%} over control values (P < 0.005). The responses were specific for the thiazolidine carboxylate moiety, because MgCl2 had no effect. These findings confirm the GSH deficiency hypothesis and demonstrate a specific biochemical mechanism of aging that can be nutritionally modified.",
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Correction of a Glutathione Deficiency in the Aging Mosquito Increases Its Longevity. / Richie, John; Mills, Betty Jane; Lang, Calvin A.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 184, No. 1, 01.01.1987, p. 113-117.

Research output: Contribution to journalArticle

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