Correlates of high hepatitis C virus RNA load in a cohort of HIV-negative and HIV-positive individuals with haemophilia

S. M. Gadalla, L. R. Preiss, M. E. Eyster, J. J. Goedert

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Hepatitis C virus (HCV) treatment failure and disease progression are more likely with high HCV-RNA load. Correlates of high HCV-RNA load in individuals with haemophilia are largely unknown. Among 1266 interferon naïve HCV-infected individuals with haemophilia, we compared those with high (>2 × 106 HCV-RNA copies/mL) to lower viral load, overall and stratifying on HIV co-infection status using logistic regression to calculate odds ratios (OR) and 95% confidence intervals (CI). Overall, high HCV load was independently associated with longer duration of HCV infection (P trend = 0.0001), body mass index ≥25 kg/m2 (OR = 1.4, 95% CI = 1.1-1.9), and HIV co-infection (OR = 1.4, 95% CI = 1.0-1.8). Among 795 HIV-negative participants, high HCV-RNA load was associated with older age at HCV acquisition (OR = 1.9 for >15 years vs≤2 years, Ptrend = 0.008), and lower AST/platelet ratio (Ptrend = 0.01), in addition to longer duration of HCV infection (Ptrend = 0.0008), and body mass index âyen25 kg/m2 (OR = 1.6, P = 0.005). Among 471 HIV-positive individuals, anti-retroviral therapy (ART) was the only variable associated with high HCV-RNA load (OR = 1.8, CI = 1.1-2.9 for combination ART; OR = 1.8, CI = 0.9-3.4, for other ART vs no treatment). High HCV-RNA load with haemophilia is more likely with longer duration of infection, older age at infection, higher body mass index, and antiretroviral therapy. These findings may help identify individuals at increased risk of HCV treatment failure and progression to end-stage liver disease.

Original languageEnglish (US)
Pages (from-to)161-169
Number of pages9
JournalJournal of Viral Hepatitis
Volume18
Issue number3
DOIs
StatePublished - Mar 1 2011

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Infectious Diseases
  • Virology

Fingerprint Dive into the research topics of 'Correlates of high hepatitis C virus RNA load in a cohort of HIV-negative and HIV-positive individuals with haemophilia'. Together they form a unique fingerprint.

  • Cite this