Abstract
Background: Diffusion-tensor imaging (DTI) depicts the movement of water through columns of cartilage and newly formed bone and provides information about velocity of growth and growth potential. Objective: To determine the correlation between DTI tractography parameters of the distal femoral physis and metaphysis and the height change after DTI in pubertal and post-pubertal children. Materials and methods: We retrospectively analyzed DTI images of the knee in 47 children with a mean age of 14.1 years in a 2-year period. In sagittal echoplanar DTI studies, regions of interest were placed in the femoral physis. Tractography was performed using a fractional anisotropy threshold of 0.15 and a maximum turning angle of 40°. The sample was divided to assess short-term and long-term growth after DTI. Short-term growth (n=25) was the height change between height at MRI and 1 year later. Long-term growth (n=36) was the height gain between height at MRI and at the growth plateau. Results: For the short-term group, subjects with larger tract volume (R2=0.40) and longer track lengths (R2=0.38) had larger height gains (P<0.01). For the long-term group, subjects with larger tract volume (R2=0.43) and longer track lengths (R2=0.32) had a larger height gain at the growth plateau (P<0.01). Intra- and inter-observer variability were good–excellent. Conclusion: Follow-up data of growth 1 year after DTI evaluation and at skeletal maturity confirms that DTI parameters are associated with the amount of post-imaging growth.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1192-1200 |
| Number of pages | 9 |
| Journal | Pediatric Radiology |
| Volume | 49 |
| Issue number | 9 |
| DOIs | |
| State | Published - Aug 1 2019 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Pediatrics, Perinatology, and Child Health
- Radiology Nuclear Medicine and imaging
Cite this
}
Correlation between diffusion tensor imaging parameters of the distal femoral physis and adjacent metaphysis, and subsequent adolescent growth. / Barrera, Christian A.; Bedoya, Maria A.; Delgado, Jorge; Berman, Jeffrey I.; Chauvin, Nancy; Edgar, J. Christopher; Jaramillo, Diego.
In: Pediatric Radiology, Vol. 49, No. 9, 01.08.2019, p. 1192-1200.Research output: Contribution to journal › Article
TY - JOUR
T1 - Correlation between diffusion tensor imaging parameters of the distal femoral physis and adjacent metaphysis, and subsequent adolescent growth
AU - Barrera, Christian A.
AU - Bedoya, Maria A.
AU - Delgado, Jorge
AU - Berman, Jeffrey I.
AU - Chauvin, Nancy
AU - Edgar, J. Christopher
AU - Jaramillo, Diego
PY - 2019/8/1
Y1 - 2019/8/1
N2 - Background: Diffusion-tensor imaging (DTI) depicts the movement of water through columns of cartilage and newly formed bone and provides information about velocity of growth and growth potential. Objective: To determine the correlation between DTI tractography parameters of the distal femoral physis and metaphysis and the height change after DTI in pubertal and post-pubertal children. Materials and methods: We retrospectively analyzed DTI images of the knee in 47 children with a mean age of 14.1 years in a 2-year period. In sagittal echoplanar DTI studies, regions of interest were placed in the femoral physis. Tractography was performed using a fractional anisotropy threshold of 0.15 and a maximum turning angle of 40°. The sample was divided to assess short-term and long-term growth after DTI. Short-term growth (n=25) was the height change between height at MRI and 1 year later. Long-term growth (n=36) was the height gain between height at MRI and at the growth plateau. Results: For the short-term group, subjects with larger tract volume (R2=0.40) and longer track lengths (R2=0.38) had larger height gains (P<0.01). For the long-term group, subjects with larger tract volume (R2=0.43) and longer track lengths (R2=0.32) had a larger height gain at the growth plateau (P<0.01). Intra- and inter-observer variability were good–excellent. Conclusion: Follow-up data of growth 1 year after DTI evaluation and at skeletal maturity confirms that DTI parameters are associated with the amount of post-imaging growth.
AB - Background: Diffusion-tensor imaging (DTI) depicts the movement of water through columns of cartilage and newly formed bone and provides information about velocity of growth and growth potential. Objective: To determine the correlation between DTI tractography parameters of the distal femoral physis and metaphysis and the height change after DTI in pubertal and post-pubertal children. Materials and methods: We retrospectively analyzed DTI images of the knee in 47 children with a mean age of 14.1 years in a 2-year period. In sagittal echoplanar DTI studies, regions of interest were placed in the femoral physis. Tractography was performed using a fractional anisotropy threshold of 0.15 and a maximum turning angle of 40°. The sample was divided to assess short-term and long-term growth after DTI. Short-term growth (n=25) was the height change between height at MRI and 1 year later. Long-term growth (n=36) was the height gain between height at MRI and at the growth plateau. Results: For the short-term group, subjects with larger tract volume (R2=0.40) and longer track lengths (R2=0.38) had larger height gains (P<0.01). For the long-term group, subjects with larger tract volume (R2=0.43) and longer track lengths (R2=0.32) had a larger height gain at the growth plateau (P<0.01). Intra- and inter-observer variability were good–excellent. Conclusion: Follow-up data of growth 1 year after DTI evaluation and at skeletal maturity confirms that DTI parameters are associated with the amount of post-imaging growth.
UR - http://www.scopus.com/inward/record.url?scp=85067018023&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85067018023&partnerID=8YFLogxK
U2 - 10.1007/s00247-019-04443-z
DO - 10.1007/s00247-019-04443-z
M3 - Article
C2 - 31177318
AN - SCOPUS:85067018023
VL - 49
SP - 1192
EP - 1200
JO - Pediatric Radiology
JF - Pediatric Radiology
SN - 0301-0449
IS - 9
ER -