Correlation of in vivo clot deposition with the flow characteristics in the 50 cc Penn State Artificial Heart

A preliminary study

Pramote Hochareon, Keefe B. Manning, Arnold Anthony Fontaine, John M. Tarbell, Steven Deutsch

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Flow stasis in an artificial heart may provide a situation where thrombus develops. Should part, or all, of the clot dislodge, a thromboembolism may lead to stroke(s), neurologic deficits, or even death. In an effort to determine if the regime of low shear or stasis exists, a two-dimensional particle image velocimetry (PIV) system was implemented to measure the velocity field within the 50 cc Penn State Artificial Heart. The velocity measurements were decomposed nearest the wall to obtain wall shear rates along the bottom of the chamber. The PIV measurements were made in three image planes across the depth of the chamber to reconstruct a surface distribution of the wall shear rates at the bottom over the entire heart cycle. The wall shear rate is shown to be spatially nonuniform, with persistently low wall shear rates. An area near the front edge of the chamber at the bottom showed wall shear rates not exceeding 250 s -1. This was an area of clot formation seen in vivo, suggesting a link may exist between the low wall shear rate zone and thrombus formation.

Original languageEnglish (US)
Pages (from-to)537-542
Number of pages6
JournalASAIO Journal
Volume50
Issue number6
DOIs
StatePublished - Nov 1 2004

Fingerprint

Artificial heart
Artificial Heart
Rheology
Shear deformation
Thrombosis
Thromboembolism
Neurologic Manifestations
Velocity measurement
Stroke

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering

Cite this

@article{acce70c153174c7599ec24d6359a737d,
title = "Correlation of in vivo clot deposition with the flow characteristics in the 50 cc Penn State Artificial Heart: A preliminary study",
abstract = "Flow stasis in an artificial heart may provide a situation where thrombus develops. Should part, or all, of the clot dislodge, a thromboembolism may lead to stroke(s), neurologic deficits, or even death. In an effort to determine if the regime of low shear or stasis exists, a two-dimensional particle image velocimetry (PIV) system was implemented to measure the velocity field within the 50 cc Penn State Artificial Heart. The velocity measurements were decomposed nearest the wall to obtain wall shear rates along the bottom of the chamber. The PIV measurements were made in three image planes across the depth of the chamber to reconstruct a surface distribution of the wall shear rates at the bottom over the entire heart cycle. The wall shear rate is shown to be spatially nonuniform, with persistently low wall shear rates. An area near the front edge of the chamber at the bottom showed wall shear rates not exceeding 250 s -1. This was an area of clot formation seen in vivo, suggesting a link may exist between the low wall shear rate zone and thrombus formation.",
author = "Pramote Hochareon and Manning, {Keefe B.} and Fontaine, {Arnold Anthony} and Tarbell, {John M.} and Steven Deutsch",
year = "2004",
month = "11",
day = "1",
doi = "10.1097/01.MAT.0000145694.40637.A0",
language = "English (US)",
volume = "50",
pages = "537--542",
journal = "ASAIO Journal",
issn = "1058-2916",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

Correlation of in vivo clot deposition with the flow characteristics in the 50 cc Penn State Artificial Heart : A preliminary study. / Hochareon, Pramote; Manning, Keefe B.; Fontaine, Arnold Anthony; Tarbell, John M.; Deutsch, Steven.

In: ASAIO Journal, Vol. 50, No. 6, 01.11.2004, p. 537-542.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Correlation of in vivo clot deposition with the flow characteristics in the 50 cc Penn State Artificial Heart

T2 - A preliminary study

AU - Hochareon, Pramote

AU - Manning, Keefe B.

AU - Fontaine, Arnold Anthony

AU - Tarbell, John M.

AU - Deutsch, Steven

PY - 2004/11/1

Y1 - 2004/11/1

N2 - Flow stasis in an artificial heart may provide a situation where thrombus develops. Should part, or all, of the clot dislodge, a thromboembolism may lead to stroke(s), neurologic deficits, or even death. In an effort to determine if the regime of low shear or stasis exists, a two-dimensional particle image velocimetry (PIV) system was implemented to measure the velocity field within the 50 cc Penn State Artificial Heart. The velocity measurements were decomposed nearest the wall to obtain wall shear rates along the bottom of the chamber. The PIV measurements were made in three image planes across the depth of the chamber to reconstruct a surface distribution of the wall shear rates at the bottom over the entire heart cycle. The wall shear rate is shown to be spatially nonuniform, with persistently low wall shear rates. An area near the front edge of the chamber at the bottom showed wall shear rates not exceeding 250 s -1. This was an area of clot formation seen in vivo, suggesting a link may exist between the low wall shear rate zone and thrombus formation.

AB - Flow stasis in an artificial heart may provide a situation where thrombus develops. Should part, or all, of the clot dislodge, a thromboembolism may lead to stroke(s), neurologic deficits, or even death. In an effort to determine if the regime of low shear or stasis exists, a two-dimensional particle image velocimetry (PIV) system was implemented to measure the velocity field within the 50 cc Penn State Artificial Heart. The velocity measurements were decomposed nearest the wall to obtain wall shear rates along the bottom of the chamber. The PIV measurements were made in three image planes across the depth of the chamber to reconstruct a surface distribution of the wall shear rates at the bottom over the entire heart cycle. The wall shear rate is shown to be spatially nonuniform, with persistently low wall shear rates. An area near the front edge of the chamber at the bottom showed wall shear rates not exceeding 250 s -1. This was an area of clot formation seen in vivo, suggesting a link may exist between the low wall shear rate zone and thrombus formation.

UR - http://www.scopus.com/inward/record.url?scp=10044259740&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=10044259740&partnerID=8YFLogxK

U2 - 10.1097/01.MAT.0000145694.40637.A0

DO - 10.1097/01.MAT.0000145694.40637.A0

M3 - Article

VL - 50

SP - 537

EP - 542

JO - ASAIO Journal

JF - ASAIO Journal

SN - 1058-2916

IS - 6

ER -