Correlation of Serum 3α-Androstanediol Glucuronide with Acne and Chest Hair Density in Men

Donald P. Lookingbill, Nancy Egan, Richard J. Santen, Laurence M. Demers

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

Serum 3α-androstanediol glucuronide (3α-Adiol-G) is considered to be an indicator of peripheral tissue androgen metabolism. Precursor circulating androgens are converted in peripheral tissue to dihydrotestosterone (DHT), which is ultimately metabolized to 3α-Adiol-G and secreted from the cell. Elevated serum 3α-Adiol-G concentrations have been reported in women in hyperandrogenic states. We studied 44 consecutive male medical students for chest hair density, acne, and serum dehydroepiandrosterone sulfate (DHEA-S), total testosterone (total T), free and albumin-bound (bioavailable) T (bio T), and 3α-Adiol-G concentrations. Although there was considerable overlap of serum 3α-Adiol-G values among the groups defined by hair density or acne scores, we found statistically significant correlations between serum 3α-Adiol-G and chest hairiness (P = 0.0034), acne (P = 0.0005), and a combined chest hairiness and acne score (P = 0.0018). There was no significant correlation between these clinical parameters and the levels of precursor androgens. There was, however, a strong correlation between serum 3α-Adiol-G and bio T (P = 0.0005), suggesting that in men serum 3α-Adiol-G levels may be dependent upon available free and albumin-bound T. The correlations in men of serum 3α-Adiol-G with chest hair density, acne, and the hairiness and acne index supports the hypothesis that the serum levels of 3α-Adiol-G reflect the extent of androgen action in peripheral tissues. (J Clin Endocrinol Metab 67: 986, 1988).

Original languageEnglish (US)
Pages (from-to)986-991
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume67
Issue number5
DOIs
StatePublished - Nov 1988

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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