Correlation of TGFβ1 overexpression with down-regulation of proliferation-inducing molecules in HPV-11 transformed human tissue xenografts

Medhat K. Shier, Elizabeth B. Neely, Margaret G. Ward, Mary E. Richards, Ernest C. Manders, Craig Meyers, Mary K. Howett

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

The epidemiologic association of human papillomavirus (HPV) infection with dysplasia and cervical cancer is well established. Transforming growth factor β1 (TGFβ1) has regulatory effects on a broad spectrum of cell types and is a growth inhibitory protein for epithelial cells. To examine the phenotype of experimentally generated, HPV-11 transformed human tissues, we looked at expression of TGFβ1 and a number of proliferation-enhancing molecules which are known to be regulated by TGFβ1, including bcl-2 c-myc, c-Ha-ras, c-jun and NFκB. HPV-11 transformed xenografts showed up-regulation of TGFβ1 expression and down-regulation of the expression levels of bcl-2, c-myc, c-Ha-ras, c-jun and NFκB. These results suggest that TGFβ1 may exert antiproliferative effects on HPV-11 transformed papillomas by down-regulating different proliferation-enhancing molecules.

Original languageEnglish (US)
Pages (from-to)4969-4976
Number of pages8
JournalAnticancer Research
Volume19
Issue number6 B
StatePublished - Nov 1999

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Correlation of TGFβ1 overexpression with down-regulation of proliferation-inducing molecules in HPV-11 transformed human tissue xenografts'. Together they form a unique fingerprint.

  • Cite this

    Shier, M. K., Neely, E. B., Ward, M. G., Richards, M. E., Manders, E. C., Meyers, C., & Howett, M. K. (1999). Correlation of TGFβ1 overexpression with down-regulation of proliferation-inducing molecules in HPV-11 transformed human tissue xenografts. Anticancer Research, 19(6 B), 4969-4976.