Correlation of TGFβ1 overexpression with down-regulation of proliferation-inducing molecules in HPV-11 transformed human tissue xenografts

Medhat K. Shier, Elizabeth B. Neely, Margaret G. Ward, Mary E. Richards, Ernest C. Manders, Craig Meyers, Mary K. Howett

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The epidemiologic association of human papillomavirus (HPV) infection with dysplasia and cervical cancer is well established. Transforming growth factor β1 (TGFβ1) has regulatory effects on a broad spectrum of cell types and is a growth inhibitory protein for epithelial cells. To examine the phenotype of experimentally generated, HPV-11 transformed human tissues, we looked at expression of TGFβ1 and a number of proliferation-enhancing molecules which are known to be regulated by TGFβ1, including bcl-2 c-myc, c-Ha-ras, c-jun and NFκB. HPV-11 transformed xenografts showed up-regulation of TGFβ1 expression and down-regulation of the expression levels of bcl-2, c-myc, c-Ha-ras, c-jun and NFκB. These results suggest that TGFβ1 may exert antiproliferative effects on HPV-11 transformed papillomas by down-regulating different proliferation-enhancing molecules.

Original languageEnglish (US)
Pages (from-to)4969-4976
Number of pages8
JournalAnticancer Research
Volume19
Issue number6 B
StatePublished - Nov 1 1999

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Human papillomavirus 11
Transforming Growth Factors
Heterografts
Down-Regulation
Papillomavirus Infections
Papilloma
Uterine Cervical Neoplasms
Up-Regulation
Epithelial Cells
Phenotype

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Shier, M. K., Neely, E. B., Ward, M. G., Richards, M. E., Manders, E. C., Meyers, C., & Howett, M. K. (1999). Correlation of TGFβ1 overexpression with down-regulation of proliferation-inducing molecules in HPV-11 transformed human tissue xenografts. Anticancer Research, 19(6 B), 4969-4976.
Shier, Medhat K. ; Neely, Elizabeth B. ; Ward, Margaret G. ; Richards, Mary E. ; Manders, Ernest C. ; Meyers, Craig ; Howett, Mary K. / Correlation of TGFβ1 overexpression with down-regulation of proliferation-inducing molecules in HPV-11 transformed human tissue xenografts. In: Anticancer Research. 1999 ; Vol. 19, No. 6 B. pp. 4969-4976.
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Shier, MK, Neely, EB, Ward, MG, Richards, ME, Manders, EC, Meyers, C & Howett, MK 1999, 'Correlation of TGFβ1 overexpression with down-regulation of proliferation-inducing molecules in HPV-11 transformed human tissue xenografts', Anticancer Research, vol. 19, no. 6 B, pp. 4969-4976.

Correlation of TGFβ1 overexpression with down-regulation of proliferation-inducing molecules in HPV-11 transformed human tissue xenografts. / Shier, Medhat K.; Neely, Elizabeth B.; Ward, Margaret G.; Richards, Mary E.; Manders, Ernest C.; Meyers, Craig; Howett, Mary K.

In: Anticancer Research, Vol. 19, No. 6 B, 01.11.1999, p. 4969-4976.

Research output: Contribution to journalArticle

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