Coupled flow-structure-biochemistry simulations of dynamic systems of blood cells using an adaptive surface tracking method

M. H. Hoskins, R. F. Kunz, J. E. Bistline, C. Dong

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

A method for the computation of low-Reynolds number dynamic blood cell systems is presented. The specific system of interest here is interaction between cancer cells and white blood cells in an experimental flow system. Fluid dynamics, structural mechanics, six-degree-of-freedom motion control, and surface biochemistry analysis components are coupled in the context of adaptive octree-based grid generation. Analytical and numerical verification of the quasi-steady assumption for the fluid mechanics is presented. The capabilities of the technique are demonstrated by presenting several three-dimensional cell system simulations, including the collision/interaction between a cancer cell and an endothelium adherent polymorphonuclear leukocyte (PMN) cell in a shear flow.

Original languageEnglish (US)
Pages (from-to)936-953
Number of pages18
JournalJournal of Fluids and Structures
Volume25
Issue number5
DOIs
StatePublished - Jul 2009

All Science Journal Classification (ASJC) codes

  • Mechanical Engineering

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