Coupled motions in enzyme catalysis

Vishal C. Nashine, Sharon Hammes-Schiffer, Stephen Benkovic

Research output: Contribution to journalReview article

117 Citations (Scopus)

Abstract

Recently, the hypothesis that protein motions are involved in enzymatic turnover has gained significant attention. We review cases where there is evidence that protein motions are rate-limiting in the overall catalytic cycle and examine experimental and theoretical evidence for how such motions enhance the probability of sampling the transition state configurations relative to the ground state. The impact of tunneling, the possible role of vibrational coupling and the value of conformational chemical landscapes are also scrutinized.

Original languageEnglish (US)
Pages (from-to)644-651
Number of pages8
JournalCurrent Opinion in Chemical Biology
Volume14
Issue number5
DOIs
StatePublished - Oct 1 2010

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Catalysis
Enzymes
Electron transitions
Ground state
Proteins
Sampling

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry

Cite this

Nashine, V. C., Hammes-Schiffer, S., & Benkovic, S. (2010). Coupled motions in enzyme catalysis. Current Opinion in Chemical Biology, 14(5), 644-651. https://doi.org/10.1016/j.cbpa.2010.07.020
Nashine, Vishal C. ; Hammes-Schiffer, Sharon ; Benkovic, Stephen. / Coupled motions in enzyme catalysis. In: Current Opinion in Chemical Biology. 2010 ; Vol. 14, No. 5. pp. 644-651.
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Nashine, VC, Hammes-Schiffer, S & Benkovic, S 2010, 'Coupled motions in enzyme catalysis', Current Opinion in Chemical Biology, vol. 14, no. 5, pp. 644-651. https://doi.org/10.1016/j.cbpa.2010.07.020

Coupled motions in enzyme catalysis. / Nashine, Vishal C.; Hammes-Schiffer, Sharon; Benkovic, Stephen.

In: Current Opinion in Chemical Biology, Vol. 14, No. 5, 01.10.2010, p. 644-651.

Research output: Contribution to journalReview article

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