Coupled vesicle morphogenesis and domain organization

Changjin Huang, Hongyan Yuan, Sulin Zhang

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Protein-enriched membrane domains with distinct biophysical properties have been thought as the basic organizing units of cellular membrane. Using particle dynamics simulations, here we study phase separation dynamics and domain formation in binary vesicles. Our simulations clearly show the intimate coupling between domain compositions, lateral domain organization, and vesicle shape transformation. Our simulation results provide insights into the essential role of membrane domains in the coordinated remodeling of cellular membranes and in protein and lipid sorting.

Original languageEnglish (US)
Article number043702
JournalApplied Physics Letters
Volume98
Issue number4
DOIs
StatePublished - Jan 24 2011

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy (miscellaneous)

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