Coupling pre-mRNA splicing and 3′ end formation to mRNA export: Alternative ways to punch the nuclear export clock

Reyad A. Elbarbary, Lynne E. Maquat

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

How does a mammalian cell determine when newly synthesized mRNAs are fully processed and appropriate for nuclear export? Müller-McNicoll and colleagues (pp. 553–566) expand on mechanisms known to be mediated by nuclear export factor 1 (NXF1) by describing SR proteins as NXF1 adaptors that flag alternatively spliced and polyadenylated mRNA isoforms as cargo ready for the cytoplasm.

Original languageEnglish (US)
Pages (from-to)487-488
Number of pages2
JournalGenes and Development
Volume30
Issue number5
DOIs
StatePublished - Mar 1 2016

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Cell Nucleus Active Transport
RNA Precursors
NFI Transcription Factors
Messenger RNA
RNA Isoforms
Cytoplasm
Proteins

All Science Journal Classification (ASJC) codes

  • Genetics
  • Developmental Biology

Cite this

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Coupling pre-mRNA splicing and 3′ end formation to mRNA export : Alternative ways to punch the nuclear export clock. / Elbarbary, Reyad A.; Maquat, Lynne E.

In: Genes and Development, Vol. 30, No. 5, 01.03.2016, p. 487-488.

Research output: Contribution to journalArticle

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