Coupling pre-mRNA splicing and 3′ end formation to mRNA export: Alternative ways to punch the nuclear export clock

Reyad A. Elbarbary; Lynne E. Maquat

doi:10.1101/gad.278937.116

Coupling pre-mRNA splicing and 3′ end formation to mRNA export: Alternative ways to punch the nuclear export clock

Reyad A. Elbarbary, Lynne E. Maquat

Department of Orthopaedics and Rehabilitation

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

How does a mammalian cell determine when newly synthesized mRNAs are fully processed and appropriate for nuclear export? Müller-McNicoll and colleagues (pp. 553–566) expand on mechanisms known to be mediated by nuclear export factor 1 (NXF1) by describing SR proteins as NXF1 adaptors that flag alternatively spliced and polyadenylated mRNA isoforms as cargo ready for the cytoplasm.

Original language	English (US)
Pages (from-to)	487-488
Number of pages	2
Journal	Genes and Development
Volume	30
Issue number	5
DOIs	https://doi.org/10.1101/gad.278937.116
State	Published - Mar 1 2016

All Science Journal Classification (ASJC) codes

Genetics
Developmental Biology

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abstract = "How does a mammalian cell determine when newly synthesized mRNAs are fully processed and appropriate for nuclear export? M{\"u}ller-McNicoll and colleagues (pp. 553–566) expand on mechanisms known to be mediated by nuclear export factor 1 (NXF1) by describing SR proteins as NXF1 adaptors that flag alternatively spliced and polyadenylated mRNA isoforms as cargo ready for the cytoplasm.",

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Coupling pre-mRNA splicing and 3′ end formation to mRNA export: Alternative ways to punch the nuclear export clock

Abstract

All Science Journal Classification (ASJC) codes

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