Cox's proportional hazards model with Lp penalty for biomarker identification and survival prediction

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Advances in high throughput technology provide massive high dimensional data. It is very important and challenging to study the association of genes with various clinical outcomes. Due to large variability in time to certain clinical event among patients, studying possibly censored survival data can be more informative than classification. We proposed the Cox's proportional hazards model with Lp penalty method for simultaneous feature (gene) selection and survival prediction. Lp penalty shrinks coefficients and produces some coefficients that are exactly zero. It has been shown that Lp (p < 1) regularization performs better than L1 in the regression and classification framework (Knight & Fu 2000, Liu et al. 2007). Experimental results with different data demonstrate that the proposed procedures can be used for identifying important genes (features) that are related to time to death due to cancer and for building parsimonious model for predicting the survival of future patients.

Original languageEnglish (US)
Title of host publicationProceedings - 6th International Conference on Machine Learning and Applications, ICMLA 2007
Pages624-628
Number of pages5
DOIs
StatePublished - Dec 1 2007
Event6th International Conference on Machine Learning and Applications, ICMLA 2007 - Cincinnati, OH, United States
Duration: Dec 13 2007Dec 15 2007

Other

Other6th International Conference on Machine Learning and Applications, ICMLA 2007
CountryUnited States
CityCincinnati, OH
Period12/13/0712/15/07

Fingerprint

Biomarkers
Identification (control systems)
Hazards
Genes
Throughput
Association reactions

All Science Journal Classification (ASJC) codes

  • Computer Science Applications
  • Human-Computer Interaction
  • Control and Systems Engineering

Cite this

Liu, Z. (2007). Cox's proportional hazards model with Lp penalty for biomarker identification and survival prediction. In Proceedings - 6th International Conference on Machine Learning and Applications, ICMLA 2007 (pp. 624-628). [4457299] https://doi.org/10.1109/ICMLA.2007.37
Liu, Zhenqiu. / Cox's proportional hazards model with Lp penalty for biomarker identification and survival prediction. Proceedings - 6th International Conference on Machine Learning and Applications, ICMLA 2007. 2007. pp. 624-628
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Liu, Z 2007, Cox's proportional hazards model with Lp penalty for biomarker identification and survival prediction. in Proceedings - 6th International Conference on Machine Learning and Applications, ICMLA 2007., 4457299, pp. 624-628, 6th International Conference on Machine Learning and Applications, ICMLA 2007, Cincinnati, OH, United States, 12/13/07. https://doi.org/10.1109/ICMLA.2007.37

Cox's proportional hazards model with Lp penalty for biomarker identification and survival prediction. / Liu, Zhenqiu.

Proceedings - 6th International Conference on Machine Learning and Applications, ICMLA 2007. 2007. p. 624-628 4457299.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Liu Z. Cox's proportional hazards model with Lp penalty for biomarker identification and survival prediction. In Proceedings - 6th International Conference on Machine Learning and Applications, ICMLA 2007. 2007. p. 624-628. 4457299 https://doi.org/10.1109/ICMLA.2007.37