CRISPR-based detection of SARS-CoV-2: A review from sample to result

Reza Nouri, Zifan Tang, Ming Dong, Tianyi Liu, Aneesh Kshirsagar, Weihua Guan

Research output: Contribution to journalReview articlepeer-review

Abstract

The current pandemic of the 2019 novel coronavirus (COVID-19) caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2) has raised significant public health concern. Rapid, affordable, and accurate diagnostics of SARS-CoV-2 is essential for early treatment and control of the disease spread. In the past few years, CRISPR technology has shown great potential for highly sensitive and specific molecular diagnostics. Amid the ongoing COVID-19 pandemic, there is an increasing interest in implementing CRISPR-based diagnostic principles to develop fast and precise methods for detecting SARS-CoV-2. In this work, we reviewed and summarized these CRISPR-based diagnostic systems as well as their characteristics and challenges. We also provided future perspectives of CRISPR-based sensing towards point-of-care molecular diagnosis applications.

Original languageEnglish (US)
Article number113012
JournalBiosensors and Bioelectronics
Volume178
DOIs
StatePublished - Apr 15 2021

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biophysics
  • Biomedical Engineering
  • Electrochemistry

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