Critical Windows for Associations between Manganese Exposure during Pregnancy and Size at Birth: A Longitudinal Cohort Study in Wuhan, China

Jie Hu, Chuansha Wu, Tongzhang Zheng, Bin Zhang, Wei Xia, Yang Peng, Wenyu Liu, Minmin Jiang, Simin Liu, Stephen L. Buka, Aifen Zhou, Yiming Zhang, Yangqian Jiang, Chen Hu, Xiaomei Chen, Qiang Zeng, Xi Chen, Bing Xu, Xichi Zhang, Ashley TruongKunchong Shi, Zhengmin Qian, Yuanyuan Li, Shunqing Xu

Research output: Contribution to journalArticle

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Abstract

BACKGROUND: Prenatal overexposure to manganese (Mn), an essential micronutrient, is related to impaired fetal growth and development. Fetuses appear to be highly sensitive to Mn during short periods of gestation. However, little is known about the critical windows of susceptibility to Mn for humans. OBJECTIVES: Our objective was to estimate trimester-specific associations of exposure to Mn with size at birth. METHODS: Urine samples of 3,022 women were collected repeatedly in the first, second, and third trimesters in Wuhan, China. Urinary concentrations of Mn and other toxic metals were measured using an inductively coupled plasma mass spectrometry. Trimester-specific associations of specific gravity–adjusted urinary Mn concentrations with birth weight, birth length, and ponderal index were estimated using multivariable linear regressions with generalized estimating equations. Linear mixed models were applied to evaluate the windows of susceptibility to Mn exposure by comparing the pattern of Mn exposure among newborns with restricted size at birth to those without. RESULTS: When compared with the third quintile of urinary Mn concentrations, both higher and lower quintiles of urinary Mn concentrations in the second and third trimesters were related to reduced birth weight, birth length, and ponderal index. But the observed associations for higher quintiles were stronger and more likely to be statistically significant [e.g., for women who were in the fifth quintile of Mn concentration in the third trimester, the reduction in birth weight was [Formula: see text] (95% CI: [Formula: see text], [Formula: see text]) g and in birth length was [Formula: see text] (95% CI: [Formula: see text], 0.00) cm]. Moreover, newborns with restricted size at birth, compared with those without, had higher levels of Mn exposure in the second and third trimesters. CONCLUSIONS: This prospective prenatal cohort study revealed an association of exposure to Mn during pregnancy, especially late pregnancy, with restricted size at birth. Replications are needed. https://doi.org/10.1289/EHP3423.

Original languageEnglish (US)
Number of pages1
JournalEnvironmental health perspectives
Volume126
Issue number12
DOIs
StatePublished - Dec 1 2018

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Manganese
Longitudinal Studies
China
Cohort Studies
Parturition
Pregnancy
Third Pregnancy Trimester
Second Pregnancy Trimester
Birth Weight
Fetal Development
Linear Models
Newborn Infant
Weights and Measures
Micronutrients
Poisons
First Pregnancy Trimester
Growth and Development
Mass Spectrometry
Fetus
Metals

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Hu, Jie ; Wu, Chuansha ; Zheng, Tongzhang ; Zhang, Bin ; Xia, Wei ; Peng, Yang ; Liu, Wenyu ; Jiang, Minmin ; Liu, Simin ; Buka, Stephen L. ; Zhou, Aifen ; Zhang, Yiming ; Jiang, Yangqian ; Hu, Chen ; Chen, Xiaomei ; Zeng, Qiang ; Chen, Xi ; Xu, Bing ; Zhang, Xichi ; Truong, Ashley ; Shi, Kunchong ; Qian, Zhengmin ; Li, Yuanyuan ; Xu, Shunqing. / Critical Windows for Associations between Manganese Exposure during Pregnancy and Size at Birth : A Longitudinal Cohort Study in Wuhan, China. In: Environmental health perspectives. 2018 ; Vol. 126, No. 12.
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title = "Critical Windows for Associations between Manganese Exposure during Pregnancy and Size at Birth: A Longitudinal Cohort Study in Wuhan, China",
abstract = "BACKGROUND: Prenatal overexposure to manganese (Mn), an essential micronutrient, is related to impaired fetal growth and development. Fetuses appear to be highly sensitive to Mn during short periods of gestation. However, little is known about the critical windows of susceptibility to Mn for humans. OBJECTIVES: Our objective was to estimate trimester-specific associations of exposure to Mn with size at birth. METHODS: Urine samples of 3,022 women were collected repeatedly in the first, second, and third trimesters in Wuhan, China. Urinary concentrations of Mn and other toxic metals were measured using an inductively coupled plasma mass spectrometry. Trimester-specific associations of specific gravity–adjusted urinary Mn concentrations with birth weight, birth length, and ponderal index were estimated using multivariable linear regressions with generalized estimating equations. Linear mixed models were applied to evaluate the windows of susceptibility to Mn exposure by comparing the pattern of Mn exposure among newborns with restricted size at birth to those without. RESULTS: When compared with the third quintile of urinary Mn concentrations, both higher and lower quintiles of urinary Mn concentrations in the second and third trimesters were related to reduced birth weight, birth length, and ponderal index. But the observed associations for higher quintiles were stronger and more likely to be statistically significant [e.g., for women who were in the fifth quintile of Mn concentration in the third trimester, the reduction in birth weight was [Formula: see text] (95{\%} CI: [Formula: see text], [Formula: see text]) g and in birth length was [Formula: see text] (95{\%} CI: [Formula: see text], 0.00) cm]. Moreover, newborns with restricted size at birth, compared with those without, had higher levels of Mn exposure in the second and third trimesters. CONCLUSIONS: This prospective prenatal cohort study revealed an association of exposure to Mn during pregnancy, especially late pregnancy, with restricted size at birth. Replications are needed. https://doi.org/10.1289/EHP3423.",
author = "Jie Hu and Chuansha Wu and Tongzhang Zheng and Bin Zhang and Wei Xia and Yang Peng and Wenyu Liu and Minmin Jiang and Simin Liu and Buka, {Stephen L.} and Aifen Zhou and Yiming Zhang and Yangqian Jiang and Chen Hu and Xiaomei Chen and Qiang Zeng and Xi Chen and Bing Xu and Xichi Zhang and Ashley Truong and Kunchong Shi and Zhengmin Qian and Yuanyuan Li and Shunqing Xu",
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Hu, J, Wu, C, Zheng, T, Zhang, B, Xia, W, Peng, Y, Liu, W, Jiang, M, Liu, S, Buka, SL, Zhou, A, Zhang, Y, Jiang, Y, Hu, C, Chen, X, Zeng, Q, Chen, X, Xu, B, Zhang, X, Truong, A, Shi, K, Qian, Z, Li, Y & Xu, S 2018, 'Critical Windows for Associations between Manganese Exposure during Pregnancy and Size at Birth: A Longitudinal Cohort Study in Wuhan, China', Environmental health perspectives, vol. 126, no. 12. https://doi.org/10.1289/EHP3423

Critical Windows for Associations between Manganese Exposure during Pregnancy and Size at Birth : A Longitudinal Cohort Study in Wuhan, China. / Hu, Jie; Wu, Chuansha; Zheng, Tongzhang; Zhang, Bin; Xia, Wei; Peng, Yang; Liu, Wenyu; Jiang, Minmin; Liu, Simin; Buka, Stephen L.; Zhou, Aifen; Zhang, Yiming; Jiang, Yangqian; Hu, Chen; Chen, Xiaomei; Zeng, Qiang; Chen, Xi; Xu, Bing; Zhang, Xichi; Truong, Ashley; Shi, Kunchong; Qian, Zhengmin; Li, Yuanyuan; Xu, Shunqing.

In: Environmental health perspectives, Vol. 126, No. 12, 01.12.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Critical Windows for Associations between Manganese Exposure during Pregnancy and Size at Birth

T2 - A Longitudinal Cohort Study in Wuhan, China

AU - Hu, Jie

AU - Wu, Chuansha

AU - Zheng, Tongzhang

AU - Zhang, Bin

AU - Xia, Wei

AU - Peng, Yang

AU - Liu, Wenyu

AU - Jiang, Minmin

AU - Liu, Simin

AU - Buka, Stephen L.

AU - Zhou, Aifen

AU - Zhang, Yiming

AU - Jiang, Yangqian

AU - Hu, Chen

AU - Chen, Xiaomei

AU - Zeng, Qiang

AU - Chen, Xi

AU - Xu, Bing

AU - Zhang, Xichi

AU - Truong, Ashley

AU - Shi, Kunchong

AU - Qian, Zhengmin

AU - Li, Yuanyuan

AU - Xu, Shunqing

PY - 2018/12/1

Y1 - 2018/12/1

N2 - BACKGROUND: Prenatal overexposure to manganese (Mn), an essential micronutrient, is related to impaired fetal growth and development. Fetuses appear to be highly sensitive to Mn during short periods of gestation. However, little is known about the critical windows of susceptibility to Mn for humans. OBJECTIVES: Our objective was to estimate trimester-specific associations of exposure to Mn with size at birth. METHODS: Urine samples of 3,022 women were collected repeatedly in the first, second, and third trimesters in Wuhan, China. Urinary concentrations of Mn and other toxic metals were measured using an inductively coupled plasma mass spectrometry. Trimester-specific associations of specific gravity–adjusted urinary Mn concentrations with birth weight, birth length, and ponderal index were estimated using multivariable linear regressions with generalized estimating equations. Linear mixed models were applied to evaluate the windows of susceptibility to Mn exposure by comparing the pattern of Mn exposure among newborns with restricted size at birth to those without. RESULTS: When compared with the third quintile of urinary Mn concentrations, both higher and lower quintiles of urinary Mn concentrations in the second and third trimesters were related to reduced birth weight, birth length, and ponderal index. But the observed associations for higher quintiles were stronger and more likely to be statistically significant [e.g., for women who were in the fifth quintile of Mn concentration in the third trimester, the reduction in birth weight was [Formula: see text] (95% CI: [Formula: see text], [Formula: see text]) g and in birth length was [Formula: see text] (95% CI: [Formula: see text], 0.00) cm]. Moreover, newborns with restricted size at birth, compared with those without, had higher levels of Mn exposure in the second and third trimesters. CONCLUSIONS: This prospective prenatal cohort study revealed an association of exposure to Mn during pregnancy, especially late pregnancy, with restricted size at birth. Replications are needed. https://doi.org/10.1289/EHP3423.

AB - BACKGROUND: Prenatal overexposure to manganese (Mn), an essential micronutrient, is related to impaired fetal growth and development. Fetuses appear to be highly sensitive to Mn during short periods of gestation. However, little is known about the critical windows of susceptibility to Mn for humans. OBJECTIVES: Our objective was to estimate trimester-specific associations of exposure to Mn with size at birth. METHODS: Urine samples of 3,022 women were collected repeatedly in the first, second, and third trimesters in Wuhan, China. Urinary concentrations of Mn and other toxic metals were measured using an inductively coupled plasma mass spectrometry. Trimester-specific associations of specific gravity–adjusted urinary Mn concentrations with birth weight, birth length, and ponderal index were estimated using multivariable linear regressions with generalized estimating equations. Linear mixed models were applied to evaluate the windows of susceptibility to Mn exposure by comparing the pattern of Mn exposure among newborns with restricted size at birth to those without. RESULTS: When compared with the third quintile of urinary Mn concentrations, both higher and lower quintiles of urinary Mn concentrations in the second and third trimesters were related to reduced birth weight, birth length, and ponderal index. But the observed associations for higher quintiles were stronger and more likely to be statistically significant [e.g., for women who were in the fifth quintile of Mn concentration in the third trimester, the reduction in birth weight was [Formula: see text] (95% CI: [Formula: see text], [Formula: see text]) g and in birth length was [Formula: see text] (95% CI: [Formula: see text], 0.00) cm]. Moreover, newborns with restricted size at birth, compared with those without, had higher levels of Mn exposure in the second and third trimesters. CONCLUSIONS: This prospective prenatal cohort study revealed an association of exposure to Mn during pregnancy, especially late pregnancy, with restricted size at birth. Replications are needed. https://doi.org/10.1289/EHP3423.

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