Cross-neutralization of cutaneous and mucosal Papillomavirus types with anti-sera to the amino terminus of L2

Diana V. Pastrana, Ratish Gambhira, Christopher B. Buck, Yuk Ying S Pang, Cynthia D. Thompson, Timothy D. Culp, Neil Christensen, Douglas R. Lowy, John T. Schiller, Richard B S Roden

Research output: Contribution to journalArticle

138 Citations (Scopus)

Abstract

Vaccination with papillomavirus L2 has been shown to induce neutralizing antibodies that protect against homologous type infection and cross-neutralize a limited number of genital HPVs. Surprisingly, we found that antibodies to bovine papillomavirus (BPV1) L2 amino acids 1-88 induced similar titers of neutralizing antibodies against Human papillomavirus (HPV)16 and 18 and BPV1 pseudoviruses and also neutralized HPV11 native virions. These antibodies also neutralized each of the other pseudovirus types tested, HPV31, HPV6 and Cottontail rabbit papillomavirus (CRPV) pseudoviruses, albeit with lower titers. HPV16, HPV18, HPV31, HPV6 and CRPV L2 anti-sera also displayed some cross-neutralization, but the titers were lower and did not encompass all pseudoviruses tested. This study demonstrates the presence of broadly cross-neutralizing epitopes at the N-terminus of L2 that are shared by cutaneous and mucosal types and by types that infect divergent species. BPV1 L2 was exceptionally effective at inducing cross-neutralizing antibodies to these shared epitopes.

Original languageEnglish (US)
Pages (from-to)365-372
Number of pages8
JournalVirology
Volume337
Issue number2
DOIs
StatePublished - Jul 5 2005

Fingerprint

Cottontail rabbit papillomavirus
Neutralizing Antibodies
Skin
Epitopes
Serum
Human papillomavirus 18
Human papillomavirus 16
Antibodies
Cross Infection
Virion
Vaccination
Amino Acids

All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases

Cite this

Pastrana, D. V., Gambhira, R., Buck, C. B., Pang, Y. Y. S., Thompson, C. D., Culp, T. D., ... Roden, R. B. S. (2005). Cross-neutralization of cutaneous and mucosal Papillomavirus types with anti-sera to the amino terminus of L2. Virology, 337(2), 365-372. https://doi.org/10.1016/j.virol.2005.04.011
Pastrana, Diana V. ; Gambhira, Ratish ; Buck, Christopher B. ; Pang, Yuk Ying S ; Thompson, Cynthia D. ; Culp, Timothy D. ; Christensen, Neil ; Lowy, Douglas R. ; Schiller, John T. ; Roden, Richard B S. / Cross-neutralization of cutaneous and mucosal Papillomavirus types with anti-sera to the amino terminus of L2. In: Virology. 2005 ; Vol. 337, No. 2. pp. 365-372.
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Pastrana, DV, Gambhira, R, Buck, CB, Pang, YYS, Thompson, CD, Culp, TD, Christensen, N, Lowy, DR, Schiller, JT & Roden, RBS 2005, 'Cross-neutralization of cutaneous and mucosal Papillomavirus types with anti-sera to the amino terminus of L2', Virology, vol. 337, no. 2, pp. 365-372. https://doi.org/10.1016/j.virol.2005.04.011

Cross-neutralization of cutaneous and mucosal Papillomavirus types with anti-sera to the amino terminus of L2. / Pastrana, Diana V.; Gambhira, Ratish; Buck, Christopher B.; Pang, Yuk Ying S; Thompson, Cynthia D.; Culp, Timothy D.; Christensen, Neil; Lowy, Douglas R.; Schiller, John T.; Roden, Richard B S.

In: Virology, Vol. 337, No. 2, 05.07.2005, p. 365-372.

Research output: Contribution to journalArticle

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